RT Journal Article
T1 Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance
A1 Quiñones Téllez, María del Mar
A1 Martínez Grobas, Eva
A1 Fernø, Johan
A1 Pérez Lois, Raquel
A1 Seoane, María Luisa
A1 Al-Massadi Iglesias, Omar
K1 SIRT1
K1 SIRT6
K1 Energy balance
K1 Food intake
K1 Body weight
K1 Adiposity
K1 Type 2 diabetes
K1 Obesity
AB Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven mammalian sirtuins (SIRT 1-7) have been identified, with SIRT1 and SIRT6 shown to exert their metabolic actions in the hypothalamus, both with crucial roles in eliciting responses to dampen metabolic complications associated with obesity. Therefore, our aim is to compile the current understanding on the role of SIRT1 and SIRT6 in the hypothalamus, especially highlighting their actions on the control of energy balance
PB MDPI
YR 2021
FD 2021
LK http://hdl.handle.net/10347/24452
UL http://hdl.handle.net/10347/24452
LA eng
NO Int. J. Mol. Sci. 2021, 22(3), 1430; https://doi.org/10.3390/ijms22031430
NO This work is supported by grants of Xunta de Galicia (MQ:2018-PG013). Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. Western Norway Regional Health Authority (Helse Vest RHF).M.Q. is a recipient of a Postdoctoral contract from Galician Government (Xunta de Galicia ED481B2018/004). O.A.M. was funded by a research contract Miguel Servet (CP20/00146) from the ISCIII
DS Minerva
RD 23 abr 2026