RT Dissertation/Thesis
T1 Atropine-loaded contact lenses for myopia control: design and preclinical evaluation
A1 García del Valle, Inés Ángela
K1 myopia
K1 atropine
K1 hydrogel
K1 medicated contact lenses
K1 controlled release
AB Myopia is a global public health priority due to its increasingprevalence in children. This PhD Thesis was aimed to thedesign of contact lenses (CLs) that load and elutetherapeutically relevant amounts of atropine for a dual physicaland pharmacological intervention. Functional monomers ofdifferent nature were combined at specific ratios to modulatethe amounts of drug loaded and to achieve sustained release.The preclinical evaluation of atropine-loaded CLs included invivo models to assess ocular tissue distribution and penetrationto the posterior segment. Parameters of the synthesizedhydrogels related to CLs comfort and wearability werecharacterized, including oxygen permeability. The findingssupport the possibility of obtaining dual prospectiveinterventions for the control of myopia progression.
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34976
UL http://hdl.handle.net/10347/34976
LA eng
DS Minerva
RD 28 abr 2026