RT Journal Article
T1 Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice
A1 Folgueira Cobos, Cintia
A1 Beiroa Tarrío, Daniel
A1 González Rellán, María Jesús
A1 Porteiro Couto, Begoña
A1 Milbank, Edward
A1 Castelao Taboada, Cecilia
A1 García Palacios, María
A1 Casanueva Freijo, Felipe
A1 López Pérez, Miguel A.
A1 Diéguez González, Carlos
A1 Seoane Camino, Luisa María
A1 Nogueiras Pozo, Rubén
K1 Uroguanylin
K1 Leptin
K1 Food intake
K1 Body weight
K1 Hypothalamus
AB The gastrointestinal-brain axis is a key mediator of the body weight and energy homeostasis regulation. Uroguanylin (UGN) has been recently proposed to be a part of this gut-brain axis regulating food intake, body weight and energy expenditure. Expression of UGN is regulated by the nutritional status and dependent on leptin levels. However, the exact molecular mechanisms underlying this UGN-leptin metabolic regulation at a hypothalamic level still remains unclear. Using leptin resistant diet-induced obese (DIO) mice, we aimed to determine whether UGN could improve hypothalamic leptin sensitivity. The present work demonstrates that the central co-administration of UGN and leptin potentiates leptin’s ability to decrease the food intake and body weight in DIO mice, and that UGN activates the hypothalamic signal transducer and activator of transcription 3 (STAT3) and phosphatidylinositide 3-kinases (PI3K) pathways. At a functional level, the blockade of PI3K, but not STAT3, blunted UGN-mediated leptin responsiveness in DIO mice. Overall, these findings indicate that UGN improves leptin sensitivity in DIO mice
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/23511
UL http://hdl.handle.net/10347/23511
LA eng
NO Folgueira, C.; Beiroa, D.; González-Rellán, M.J.; Porteiro, B.; Milbank, E.; Castelao, C.; García-Palacios, M.; Casanueva, F.F.; López, M.; Diéguez, C.; Seoane, L.M.; Nogueiras, R. Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice. Nutrients 2019, 11, 752.
NO This research was funded by grants from Instituto de Salud Carlos III (PI15/01272 and PI18/00998) cofounded by FEDER, Fundación Mutua Madrileña, MINECO (MF: BFU2016-80899-P; ML: 2015-CP079; CD: BFU2017-87721; RN: BFU2015-70664R); Xunta de Galicia (ML: SAF2015-71026-R and 2016-PG068; RN: 2015-CP080 and 2016-PG057); Fundación BBVA (RN) and Fundación Atresmedia (RN and ML). Luisa M Seoane is a SERGAS-I3SNS researcher. CIBERobn is an iniciative of the ISCIII supported by FEDER
DS Minerva
RD 28 abr 2026