RT Journal Article
T1 Recent progress in the development of immobilized penicillin G acylase for chemical and industrial applications: A mini‐review
A1 Li, Ke
A1 Alhadi Abdelrahman Mohammed, Monier
A1 Zhou, Yongshan
A1 Tu, Hongyi
A1 Zhang, Jiachen
A1 Liu, Chunli
A1 Chen, Zhenbin
A1 Burns, Robert
A1 Hu, Dongdong
A1 Ruso Beiras, Juan Manuel
A1 Tang, Zhenghua
A1 Liu, Zhen
K1 Carrier
K1 Immobilization
K1 Penicilin G acylase
K1 Reaction
K1 Reactor
AB Immobilized penicillin G acylase (PGA) as an important industrial catalyst can catalyze penicillin G potassium (PG) to 6-aminopenicillanic acid (6-APA). 6-APA is an important intermediate for semisynthetic penicillin drugs, which occupies a huge market space in the anti-inflammatory field; as a result, immobilized PGA occupies a huge market space in the pharmaceutical field. However, at present, there are different degrees of defects in the preparation and production process of immobilized PGAs on the market because of the huge demand; therefore, the performance of immobilized PGA and its productivity will bring huge economic benefits to enterprises. Therefore, research on immobilized PGA has always been a focus. This review first introduces the source, classification, structure, and catalytic mechanism of PGA and then studies the development of immobilization methods, immobilized carriers, reaction media, enzyme activity regeneration, and reactors of immobilized PGA in recent years.
PB John Wiley & Sons
YR 2019
FD 2019-09-07
LK https://hdl.handle.net/10347/43946
UL https://hdl.handle.net/10347/43946
LA eng
NO Li K, Mohammed MAA, Zhou Y, et al. Recent progress in the development of immobilized penicillin G acylase for chemical and industrial applications: A mini-review. Polym Adv Technol. 2020; 31: 368–388
NO This is the pre-peer reviewed version of the following article: Li K, Mohammed MAA, Zhou Y, et al. Recent progress in the development of immobilized penicillin G acylase for chemical and industrial applications: A mini-review. Polym Adv Technol. 2020; 31: 368–388, which has been published in final form at https://doi.org/10.1002/pat.4791. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
DS Minerva
RD 28 abr 2026