RT Journal Article
T1 Regeneration of periodontal bone defects with mesenchymal stem cells in animal models. Systematic review and meta-analysis
A1 Velasquez Ron, Byron Vinicio
A1 Chauca Bajaña, Luis Alberto
A1 Tomás Carmona, Inmaculada
A1 Camacho-Alonso, Fabio
A1 Pérez-Sayáns García, Mario
A1 Pérez Jardón, Alba
K1 Stem cells
K1 Pluripotent stem cells
K1 Periodontal defect
K1 Periodontal regeneration
AB The aim of this study was to evaluate the efficacy of mesenchymal stem cells (MSCs) in the regeneration of periodontal bone defects in animal models. A systematic review and meta-analysis were conducted following the PRISMA guidelines, and the study was recorded in PROSPERO under reference number CDR42021247462. The PICO question was: is periodontal regeneration (cementum, periodontal ligament and alveolar bone) with MSCs more effective than other techniques? Three groups were considered: Group 1: MSCs alone or mixed with regenerative materials. Group 2: only regenerative materials. Group 3: no regenerative material nor MSCs. The search was conducted using MeSH with a total of 18 articles for qualitative analysis and 5 for quantitative analysis. For the meta-analysis, a modification of the effect size algorithm was developed, which considered a comparison of means between treatments using the Student's t sample distribution. When comparing the effect size between Group 1 and Group 2, the effect size for the new cementum was 2.83 mm with an estimated confidence interval of 95% (CI 95%) between 0.48 and 5.17 mm. When considering the fit to a random-effects model, the combined variance (τ2) was 6.1573 mm, with a standard deviation (SD) of 5.6008 mm and a percentage of total heterogeneity I2 of 92.33% (p < 0.0001). For new bone, the effect size was 0.88 mm, CI 95% − 0.25 to 2.01 mm, τ2 = 1.3108 mm (SD = 1.2021 mm) and I2 = 80.46%, p = 0.0004). With regard to the new periodontal ligament, it was not possible for the meta-analysis to be performed. MSCs have a greater capacity for tissue regeneration in root cementum than in alveolar bone compared to other regenerative materials
PB Springer
SN 1618-1247
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29193
UL http://hdl.handle.net/10347/29193
LA eng
NO Odontology (2022). https://doi.org/10.1007/s10266-022-00725-5
NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was partly funded by a pre-doctoral grant (on a competitive basis) from the Health Research Institute of Santiago de Compostela that was awarded to Alba Pérez Jardón (IDIS2020/PREDOC/03)
DS Minerva
RD 28 abr 2026