RT Journal Article
T1 Indomethacin microencapsulation by coaxial ultrasonic atomization intended for intraarticular administration
A1 Lamela Gómez, Iván
A1 Luzardo Álvarez, Asteria María
K1 Indomethacin
K1 Microencapsulation
K1 NSAIDs
K1 Intra-articular
K1 Controlled release
K1 Rheumatoid arthritis
AB Indomethacin (IND) is a non-steroidal anti-inflammatory drug (NSAID) with high efficacy in the treatment of rheumatic disorders. Nonetheless, its severe adverse effects limit its first-line and long-term use, and its rapid clearance from the joint prevents its local administration. This study aims to overcome those limitations by developing an intra-articular formulation of IND-loaded microparticles made of polymeric blends of Polyactive® 1000PEOT70PBT30 and Resomer® RG502. Formulations were prepared by coaxial ultrasonic atomization according to an experimental design to assess the influence of the polymeric composition and flow rates supplied to the nozzle over particle size, encapsulation efficiency and in vitro delivery profile. Nine formulations of spherical microparticles were developed and exhaustively characterized, showing high drug entrapment (56.2–81.32 %) and suitable mean particle size for intra-articular administration (22.8–82.6 μm). In vitro evaluation of IND-loaded microparticles in THP-1 macrophages demonstrated their biocompatibility and extensive internalization by THP-1 cells, supporting their potential for macrophage targeting and particle retention into the joint. Further, IND-loaded microparticles showed high anti-inflammatory activity in vitro, significantly reducing the production of IL-6 and TNF-α by LPS-stimulated macrophages. Overall, the results support the idea that IND-loaded microcapsules are a suitable drug delivery system for the intra-articular administration of indomethacin.
PB Elsevier
SN 1773-2247
YR 2025
FD 2025-07
LK https://hdl.handle.net/10347/43435
UL https://hdl.handle.net/10347/43435
LA eng
NO Lamela-Gómez, I., & Luzardo-Álvarez, A. (2025). Indomethacin microencapsulation by coaxial ultrasonic atomization intended for intraarticular administration. Journal of Drug Delivery Science and Technology, 109, 107002. 10.1016/j.jddst.2025.107002
NO Ivan Lamela-Gomez is grateful to “Axudas a etapa predoutoral da Xunta de Galicia, cofinanciadas polo programa operativo FSE Galicia 2014-2020” predoctoral grant program. Consellería de Cultura, Educacion e ordenacion universitaria, Xunta de Galicia, Spain. This research was partially funded by Consellería de Cultura, Educacion e ordenacion universitaria, Xunta de Galicia, Spain. Axudas para a consolidacion e estructuracion de unidades de investigacion competitivas Modalidad A: Grupos de Referencia Competitiva (ED341C 2017/13).
DS Minerva
RD 24 abr 2026