RT Journal Article
T1 Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins
A1 Matos, Maria João Correia Pinto Carvalho de
A1 Pérez Cruz, Fernanda
A1 Vázquez Rodríguez, Saleta
A1 Uriarte Villares, Eugenio
A1 Santana Penín, María Lourdes
A1 Borges, Fernanda
A1 Olea Azar, Claudio
K1 3-Arylcoumarins
K1 Hydroxyl derivatives
K1 ORAC-FL assays
K1 ESR assays
K1 CV assays
K1 Antioxidant capacity
AB In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical evaluation of ADME properties of all the derivatives was also carried out. From the ORAC-FL, ESR and CV data it was concluded that these derivatives are very good antioxidants, with a very interesting hydroxyl, DPPH and superoxide radicals scavenging profiles. In particular compound 9 is the most active and effective antioxidant of the series (ORAC-FL = 13.5, capacity of scavenging hydroxyl radicals = 100%, capacity of scavenging DPPH radicals = 65.9% and capacity of scavenging superoxide radicals = 71.5%). Kinetics profile for protection fluorescein probe against peroxyl radicals by addition of antioxidant molecule 9 was also performed. Therefore, it can operate as a potential candidate for preventing or minimizing the free radicals overproduction in oxidative-stress related diseases
PB Elsevier
SN 0968-0896
YR 2013
FD 2013
LK http://hdl.handle.net/10347/24337
UL http://hdl.handle.net/10347/24337
LA eng
NO Bioorganic & Medicinal Chemistry, Volume 21, Issue 13, 1 July 2013, Pages 3900-3906
NO The current work was supported by Mecesup (Project UCH-0601), CONICYT-Chile (Project N 24110059), Fundação para a Ciência e Tecnologia (Project PTDC/QUI-QUI/113687/2009) and personal funds from the researchers. M.J. Matos thanks Fundação para a Ciência e Tecnologia (SFRH/BD/61262/2009) Ph.D. Grant, F. Pérez-Cruz thanks CONICYT-Chile PhD. grant, Becas-Chile and Fulbright doctoral stay fellowships and S. Vazquez-Rodriguez thanks Ministerio de Educación y Ciencia (AP2008-04263) PhD. Grant
DS Minerva
RD 4 may 2026