RT Journal Article
T1 Current Stage of Marine Ceramic Grafts for 3D Bone Tissue Regeneration
A1 Díaz Rodríguez, Patricia
A1 López Álvarez, Miriam
A1 Serra, Julia
A1 González, Pío
A1 Landín Pérez, Mariana
K1 Marine ceramic grafts
K1 Calcium phosphate
K1 Bone tissue regeneration
K1 Osteoinductive properties
K1 Structural strength
K1 Dissolution rate
AB Bioceramic scaffolds are crucial in tissue engineering for bone regeneration. They usually provide hierarchical porosity, bioactivity, and mechanical support supplying osteoconductive properties and allowing for 3D cell culture. In the case of age-related diseases such as osteoarthritis and osteoporosis, or other bone alterations as alveolar bone resorption or spinal fractures, functional tissue recovery usually requires the use of grafts. These bone grafts or bone void fillers are usually based on porous calcium phosphate grains which, once disposed into the bone defect, act as scaffolds by incorporating, to their own porosity, the intergranular one. Despite their routine use in traumatology and dental applications, specific graft requirements such as osteoinductivity or balanced dissolution rate are still not completely fulfilled. Marine origin bioceramics research opens the possibility to find new sources of bone grafts given the wide diversity of marine materials still largely unexplored. The interest in this field has also been urged by the limitations of synthetic or mammalian-derived grafts already in use and broadly investigated. The present review covers the current stage of major marine origin bioceramic grafts for bone tissue regeneration and their promising properties. Both products already available on the market and those in preclinical phases are included. To understand their clear contribution to the field, the main clinical requirements and the current available biological-derived ceramic grafts with their advantages and limitations have been collected.
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21147
UL http://hdl.handle.net/10347/21147
LA eng
NO Diaz-Rodriguez, P.; López-Álvarez, M.; Serra, J.; González, P.; Landín, M. Current Stage of Marine Ceramic Grafts for 3D Bone Tissue Regeneration. Mar. Drugs 2019, 17, 471
NO This research was partially supported by the European Union projects 0245_IBEROS_1_E and 0302_CVMAR_I_1_P, both from Interreg V-A Spain-Portugal (POCTEP 2015) and BLUEHUMAN EAPA_151/2016 from INTERREG Atlantic Area, European Regional Development Fund. Moreover, regional funds from Competitive Reference Groups (GRC) ED431C 2016/008 and ED431C 2017_51 and Research networks ED431D 2017/13 both from Xunta de Galicia (Spain) are also acknowledged. P. Diaz-Rodriguez and M. López-Alvarez are thankful for the funding support provided by 0245_IBEROS_1_E from EU Interreg V-A Spain-Portugal (POCTEP) project2017/13 both from Xunta de Galicia (Spain) are also acknowledged. P. Diaz-Rodriguez and M. López-Alvarezare thankful for the funding support provided by 0245_IBEROS_1_E from EU Interreg V-A Spain-Portugal(POCTEP) project.
DS Minerva
RD 24 abr 2026