RT Dissertation/Thesis
T1 Design and formulation of nanocarriers for the treatment of diabetic eye diseases
A1 Kattar, Axel
K1 Epalrestat
K1 diabetes
K1 eye
K1 niosome
K1 oleogel
AB The eye is a crucial organ that allows us to experience the world visually,and the loss of vision is a fear for many. One significant threat to eye healthis diabetic retinopathy, which can result in consequences as severe asblindness if left untreated. Current treatments for diabetic retinopathyinvolve injections and laser exposure, but they only slow down thedegeneration of the retina. Therefore, there exists a need for preventivetreatments to protect patients' vision. One potential solution is the use of asmall molecule called epalrestat, which can block a metabolic pathwayinvolved in the development of diabetic retinopathy. To enhance the deliveryof epalrestat to the eye, drug carriers have been investigated. Niosomes andoleogels were formulated, characterized, and tested in various modelsincluding ex vivo, in ovo, and in vivo assays. The self-assembly process ofthe niosomes was investigated with the help of a monolayer model. Thesecarriers provided a saf e and e:fficient way to help with the transport ofepalrestat across the various ocular barriers.
YR 2024
FD 2024
LK http://hdl.handle.net/10347/32860
UL http://hdl.handle.net/10347/32860
LA eng
DS Minerva
RD 24 abr 2026