RT Journal Article
T1 Biomimetic nanosystems for pancreatic cancer therapy: A review
A1 Pereira Silva, Miguel
A1 Veiga, Francisco José de Baptista
A1 Santos, Ana Cláudia Paiva
A1 Concheiro Nine, Ángel Joaquín
A1 Álvarez Lorenzo, Carmen
K1 Pancreatic cancer
K1 Nanoparticle
K1 Chemotherapy
K1 Biomimetic
K1 Exosome
K1 Cell membrane-coated
AB Pancreatic cancer (PC) is a highly lethal and aggressive malignancy, currently one of the leading causes of cancer-related deaths worldwide, in both women and men. PC is highly resistant to standard chemotherapy (CT) because its immunosuppressive and hypoxic tumor microenvironment and a dense desmoplastic stroma compartment extensively limit drug accessibility and perfusion. Although CT is one of the main therapeutic strategies for PC management contributing to tumor eradication through a cytotoxic effect, CT is associated with a poor pharmacokinetic profile and provokes deleterious systemic toxicity. This low efficacy-poor safety scenario urgently calls for innovative and highly specific therapeutic strategies to counteract this urgent clinical challenge. Nanotechnology-based precision materials for cancer may help improve drug stability and minimize the systemic cytotoxic effects by increasing drug tumor accumulation and also enabling controlled release, but several drawbacks still persist, such as the poor targeting efficiency. In the last few years increased attention has been paid to bioinspired nanosystems that can mimic either partially or totally biological systems, including lipid layers as suitable stealth coatings resembling the composition of cell membranes, lipoprotein- and blood protein-based nanosystems, and cell membrane-derived systems, such as extracellular vesicles, cell membrane nanovesicles and cell membrane-coated nanosystems, which display intrinsic cancer-targeting abilities, enhanced biocompatibility, decreased immunogenicity, and prolonged blood circulation profile. This review covers the recent breakthroughs on advanced biomimetic PC-targeted nanosystems, focusing on their design, properties and applications as innovative, multifunctional and versatile tools paving the way to improved PC diagnosis and treatment.
PB Elsevier
SN 0168-3659
YR 2025
FD 2025-05-08
LK https://hdl.handle.net/10347/44046
UL https://hdl.handle.net/10347/44046
LA eng
NO Pereira-Silva, M., Veiga, F., Paiva-Santos, A. C., Concheiro, A., & Alvarez-Lorenzo, C. (2025). Biomimetic nanosystems for pancreatic cancer therapy: A review. Journal of Controlled Release, 383, 113824. 10.1016/j.jconrel.2025.113824
NO This work was supported by the Fundaçao para a Ciencia e Tecnologia (FCT, Portugal) [FCT SFRH/BD/148771/2019] and the Ministerio de Ciencia e Innovacion MCIN/AEI/10.13039/501100011033 [PID2023-150422OB-I00] (Spain), Xunta de Galicia [ED431C 2024/ 09], and FEDER.
DS Minerva
RD 4 may 2026