RT Journal Article T1 Development of a QuEChERS method for simultaneous analysis of 3-Monochloropropane-1,2-diol monoesters and Glycidyl esters in edible oils and margarine by LC-APCI-MS/MS A1 Custodio Mendoza, Jorge Antonio A1 Sendón García, Raquel A1 Rodríguez Bernaldo de Quirós, Ana Isabel A1 Lorenzo Ferreira, Rosa Antonia A1 Carro Díaz, Antonia María K1 APCI K1 Food contaminants K1 Glycidyl K1 HPLC method K1 3-MCPD K1 QuEChERS AB A simple, fast and effective direct method based on HPLC-APCI-QqQ-MS/MS has been developed to simultaneously determine four 3-monochloropropane-1,2-diol monoesters (3-MCPDE) esterified with palmitic, linoleic, stearic, and oleic acid, and two glycidyl esters (GE) with palmitic and oleic acid in margarine and olive oil using a QuEChERS approach. Factors affecting the efficiency of the extraction process were assessed, including type and amount of salt, extraction solvent, test portion amount, and clean-up sorbent. The analytical method was validated according to Food and Drug Administration (FDA) guidelines using matrix-matched calibration with internal standards and showed good results in terms of linearity (r2 > 0.9992), accuracy (80