RT Journal Article
T1 The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition—The PREOBE Follow-Up
A1 Garza Puentes, Andrea de la
A1 Martí Alemany, Adrià
A1 Chisaguano, Aida Maribel
A1 Montes Goyanes, Rosa
A1 Castellote, Ana I.
A1 Torres-Espínola, Francisco J.
A1 García-Valdés, Luz
A1 Escudero-Marín, Mireia
A1 Segura, María Teresa
A1 Campoy, Cristina
A1 López-Sabater, M. Carmen
K1 Maternal obesity
K1 Breastfeeding
K1 Breast milk
K1 Colostrum
K1 Mature milk
K1 Fatty acids
K1 LC-PUFA
K1 Omega-3
K1 Omega-6
K1 DHA
K1 AA
K1 Children
K1 Growth
K1 Cognition
K1 Early life nutrition
K1 Programming
AB This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and their association with infant growth and cognition to raise awareness about the programming effect of maternal health and to promote a healthy prenatal weight. Mother–child pairs (n = 78) were grouped per maternal pre-pregnancy body mass index (BMI): normal-weight (BMI = 18.5–24.99), overweight (BMI = 25–29.99) and obese (BMI > 30). Colostrum and mature milk FAs were determined. Infant anthropometry at 6, 18 and 36 months of age and cognition at 18 were analyzed. Mature milk exhibited lower arachidonic acid (AA) and docosahexaenoic acid (DHA), among others, than colostrum. Breast milk of non-normal weight mothers presented increased saturated FAs and n6:n3 ratio and decreased α-linolenic acid (ALA), DHA and monounsaturated FAs. Infant BMI-for-age at 6 months of age was inversely associated with colostrum n6 (e.g., AA) and n3 (e.g., DHA) FAs and positively associated with n6:n3 ratio. Depending on the maternal weight, infant cognition was positively influenced by breast milk linoleic acid, n6 PUFAs, ALA, DHA and n3 LC-PUFAs, and negatively affected by n6:n3 ratio. In conclusion, this study shows that maternal pre-pregnancy BMI can influence breast milk FAs and infant growth and cognition, endorsing the importance of a healthy weight in future generations
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/20970
UL http://hdl.handle.net/10347/20970
LA eng
NO de la Garza Puentes, A.; Martí Alemany, A.; Chisaguano, A.M.; Montes Goyanes, R.; Castellote, A.I.; Torres-Espínola, F.J.; García-Valdés, L.; Escudero-Marín, M.; Segura, M.T.; Campoy, C.; López-Sabater, M.C. The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition—The PREOBE Follow-Up. Nutrients 2019, 11, 2154.
NO This research was funded by the European Commission (DynaHEALTH-HORIZON 2020 GA No: 633595)and the Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-02). Further support was obtainedfrom, Spanish Ministry of Innovation and Science (Junta de Andalucía), Excellence Projects (P06-CTS-02341).ADLGP thanks the Mexican government and the National Council on Science and Technology (CONACYT) forher PhD grant
DS Minerva
RD 28 abr 2026