RT Dissertation/Thesis
T1 Rational design of nanocarriers for oral peptide administration
A1 Niu, Zhigao
K1 nanocarriers
K1 oral peptide
K1 administration
AB Despite the increasing therapeutic potential of peptide drugs, their exploitation has beengreatly hampered due to their necessity of being injected. The possibility to deliverthese complex molecules by the oral route would highly increase their therapeutic value.However, the gastrointestinal tract (GIT) has several biological barriers that make theadministration of peptides a very important challenge. The objective of this thesis hasbeen to design and develop polymer-based peptide nanocarriers with the potential toovercome the low stability and poor intestinal permeability of these fragilemacromolecules. Beyond this ambitious objective, this thesis is expected tosignificantly contribute to the understanding of the processes involved in the interactionof the nanostructures with the GIT barriers.
YR 2016
FD 2016
LK http://hdl.handle.net/10347/16903
UL http://hdl.handle.net/10347/16903
LA eng
DS Minerva
RD 30 abr 2026