RT Journal Article
T1 Biobased short chain fatty acid production - Exploring microbial community dynamics and metabolic networks through kinetic and microbial modeling approaches
A1 Atasoy, Merve
A1 Scott Jr, William T.
A1 Regueira López, Alberte
A1 Mauricio Iglesias, Miguel
A1 Schaap, Peter J.
A1 Smidt, Hauke
K1 Volatile fatty acids
K1 Open mixed culture fermentation
K1 Microbial community
K1 Kinetic modeling
K1 Generalized-Lotka Volterra models
K1 ODE-based microbe effector models
K1 Genome-scale metabolic models
AB In recent years, there has been growing interest in harnessing anaerobic digestion technology for resource recovery from waste streams. This approach has evolved beyond its traditional role in energy generation to encompass the production of valuable carboxylic acids, especially volatile fatty acids (VFAs) like acetic acid, propionic acid, and butyric acid. VFAs hold great potential for various industries and biobased applications due to their versatile properties. Despite increasing global demand, over 90% of VFAs are currently produced synthetically from petrochemicals. Realizing the potential of large-scale biobased VFA production from waste streams offers significant eco-friendly opportunities but comes with several key challenges. These include low VFA production yields, unstable acid compositions, complex and expensive purification methods, and post-processing needs. Among these, production yield and acid composition stand out as the most critical obstacles impacting economic viability and competitiveness. This paper seeks to offer a comprehensive view of combining complementary modeling approaches, including kinetic and microbial modeling, to understand the workings of microbial communities and metabolic pathways in VFA production, enhance production efficiency, and regulate acid profiles through the integration of omics and bioreactor data.
PB Elsevier
SN 0734-9750
YR 2024
FD 2024-04-22
LK https://hdl.handle.net/10347/44005
UL https://hdl.handle.net/10347/44005
LA eng
NO Biotechnology Advances 73 (2024) 108363
DS Minerva
RD 29 abr 2026