RT Journal Article T1 A Genome-Wide Study of Modern-Day Tuscans: Revisiting Herodotus's Theory on the Origin of the Etruscans A1 Pardo Seco, Jacobo José A1 Gómez Carballa, Alberto A1 Amigo Lechuga, Jorge A1 Martinón Torres, Federico A1 Salas Ellacuriaga, Antonio AB Background: The origin of the Etruscan civilization (Etruria, Central Italy) is a long-standing subject of debate amongscholars from different disciplines. The bulk of the information has been reconstructed from ancient texts andarchaeological findings and, in the last few years, through the analysis of uniparental genetic markers.Methods: By meta-analyzing genome-wide data from The 1000 Genomes Project and the literature, we were able tocompare the genomic patterns (.540,000 SNPs) of present day Tuscans (N = 98) with other population groups from themain hypothetical source populations, namely, Europe and the Middle East.Results: Admixture analysis indicates the presence of 25–34% of Middle Eastern component in modern Tuscans. Differentanalyses have been carried out using identity-by-state (IBS) values and genetic distances point to Eastern Anatolia/SouthernCaucasus as the most likely geographic origin of the main Middle Eastern genetic component observed in the genome ofmodern Tuscans.Conclusions: The data indicate that the admixture event between local Tuscans and Middle Easterners could have occurredin Central Italy about 2,600–3,100 years ago (y.a.). On the whole, the results validate the theory of the ancient historianHerodotus on the origin of Etruscans. PB PLOS YR 2014 FD 2014 LK http://hdl.handle.net/10347/21804 UL http://hdl.handle.net/10347/21804 LA eng NO Pardo-Seco J, Gómez-Carballa A, Amigo J, Martinón-Torres F, Salas A (2014) A Genome-Wide Study of Modern-Day Tuscans: Revisiting Herodotus's Theory on the Origin of the Etruscans. PLoS ONE 9(9): e105920. https://doi.org/10.1371/journal.pone.0105920 NO The research leading to these results has received funding from the ‘‘Ministerio de Ciencia e Innovacio´n’’ (SAF2011-26983) and from the Plan GalegoIDT, Xunta de Galicia (EM 2012/045) (A.S.) and Consellerı´a de Sanidade/Xunta de Galicia (RHI07/2-intensificacio´n de la actividad investigadora and10PXIB918184PR), Instituto Carlos III (Intensificacio´n de la actividad investigadora) and Fondo de Investigacio´n Sanitaria (FIS; PI07/0069, PI10/00540 and PI13/02382) of the Plan Nacional de I+D+I and ‘fondos FEDER’ (F.M.T.). The funders had no role in study design, data collection and analysis, decision to publish, orpreparation of the manuscript. DS Minerva RD 30 abr 2026