RT Journal Article
T1 Neurogenetic asymmetries in the catshark developing habenulae: mechanistic and evolutionary implications
A1 Lagadec, Ronan
A1 Lanoizelet, Maxence
A1 Sánchez Farías, Nuria
A1 Hérard, Fanny
A1 Menuet, Arnaud
A1 Mayeur, Hélène
A1 Billoud, Bernard
A1 Rodríguez-Moldes Rey, María Isabel
A1 Candal Suárez, Eva María
A1 Mazan, Sylvie
AB Analysis of the establishment of epithalamic asymmetry in two non-conventional model organisms,a cartilaginous fsh and a lamprey, has suggested that an essential role of Nodal signalling, likely tobe ancestral in vertebrates, may have been largely lost in zebrafsh. In order to decipher the cellularmechanisms underlying this divergence, we have characterised neurogenetic asymmetries duringhabenular development in the catshark Scyliorhinus canicula and addressed the mechanism involvedin this process. As in zebrafsh, neuronal diferentiation starts earlier on the left side in the catsharkhabenulae, suggesting the conservation of a temporal regulation of neurogenesis. At later stages,marked, Alk4/5/7 dependent, size asymmetries having no clear counterparts in zebrafsh also developin neural progenitor territories, with a larger size of the proliferative, pseudostratifed neuroepithelium,in the right habenula relative to the left one, but a higher cell number on the left of a more lateral, laterformed population of neural progenitors. These data show that mechanisms resulting in an asymmetric,preferential maintenance of neural progenitors act both in the left and the right habenulae, on diferentcell populations. Such mechanisms may provide a substrate for quantitative variations accounting forthe variability in size and laterality of habenular asymmetries across vertebrates.
PB Nature Publishing Group
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22453
UL http://hdl.handle.net/10347/22453
LA eng
NO Lagadec, R., Lanoizelet, M., Sánchez-Farías, N. et al. Neurogenetic asymmetries in the catshark developing habenulae: mechanistic and evolutionary implications. Sci Rep 8, 4616 (2018). https://doi.org/10.1038/s41598-018-22851-3
NO The work was funded by CNRS, Université Pierre et Marie Curie, grant N° ANR-16-CE13-0013-02 to S.M., and grants from the Spanish Dirección General de Investigación-FEDER (BFU2014-58631-P), Xunta de Galicia-FEDER (ED341D R2016/032) to E.C. R.L. and M.L. were supported was supported by CNRS and Région Occitanie doctoral fellowships
DS Minerva
RD 24 abr 2026