RT Journal Article
T1 Trace element status in canine endocrine diseases
A1 Larrán Franco, Belén
A1 Loste, Araceli
A1 Borobia, Marta
A1 Miranda Castañón, Marta Inés
A1 López Alonso, María Marta
A1 Herrero Latorre, Carlos
A1 Marca, M. Carmen
A1 Orjales Galdo, Inmaculada
K1 Mineral
K1 Endocrinopathy
K1 Hyperadrenocorticism
K1 Hypothyroidism
K1 Diabetes mellitus
K1 Dog
AB A balanced trace element status is essential for the optimal functioning of all organisms. However, their concentrations are often altered in diverse medical conditions. This study investigated the trace element profiles in plasma samples of dogs with endocrine diseases and used chemometric techniques to explore their associations with biochemical data. Thirteen elements (As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Se and Zn) were measured in 40 dogs with hyperadrenocorticism (HAC), 29 dogs with diabetes mellitus (DM), 11 dogs with hypothyroidism (HT) and 30 control dogs using inductively coupled plasma mass spectrometry (ICP-MS). Statistically significant differences were observed for As, Cu, Mo, Se and Zn. In comparison with the control group, the HT patients had higher As and lower Se levels, while the HAC group had higher concentrations of Mo. All three disease groups had higher Cu and Zn concentrations than the control group, with the DM group having higher Cu concentrations and the HAC group higher Zn concentrations than the other endocrinopathy groups. The chemometric analysis revealed distinctive association patterns for discriminating each pathology group and the control group. Moreover, the analysis revealed the following associations: Mo with glucose levels and Cu with fructosamine levels in the DM group, As with cortisol levels in the HAC group, and Se with TT4 levels and As with TSH levels in the HT group. The study findings provide valuable insights into the complex relationships between trace elements and endocrinopathies, elucidating the associations with biochemical markers in these diseases. Larger-scale studies are necessary to fully understand the observed relationships and explore the potential clinical applications.
PB Elsevier
SN 0034-5288
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34626
UL http://hdl.handle.net/10347/34626
LA eng
NO Research in Veterinary Science Volume 174 , July 2024, 105309
NO Belén Larrán is in receipt of a FPU fellowship (Ref. FPU21/01742) from the Spanish Ministry of Education, Culture and Sports. Belén Larrán, Marta Miranda, Marta López-Alonso and Inmaculada Orjales belong to Grupo de Potencial Crecimiento financed by GAIN (Axencia Galega de Innovación; grant number ED431B 2023/008).
DS Minerva
RD 24 abr 2026