RT Journal Article
T1 Predictive value of advanced glycation endproducts for the development of post-infarctionheart failure: a preliminary report
A1 Raposeiras Roubín, Sergio
A1 Rodiño Janeiro, Bruno Kotska
A1 Paradela Dobarro, Beatriz
A1 Grigorian Shamagian, Lilian
A1 García Acuña, José María
A1 Aguiar Souto, Pablo
A1 Jacquet Hervet, Michel
A1 Reino Maceiras, María V.
A1 Álvarez, Ezequiel
A1 González Juanatey, José Ramón
K1 Advanced glycation end products
K1 Heart failure
K1 Myocardial infarct
K1 Ventricular remodelling
K1 Diabetes mellitus
AB BackgroundSince post-infarction heart failure (HF) determines a great morbidity and mortality, and given the physiopathology implications of advanced glycation end products (AGE) in the genesis of myocardial dysfunction, it was intended to analyze the prognostic value of these molecules in order to predict post-infarction HF development.MethodsA prospective clinical study in patients after first acute coronary syndrome was conducted. The follow-up period was consisted in 1 year. In 194 patients consecutively admitted in the coronary unit for myocardial infarct fluorescent AGE levels were measured. The association between glycaemic parameters and the development of post-infarction HF were analyzed in those patients. Finally, we identified the variables with independent predictor value by performing a multivariate analysis of Hazard ratio for Cox regression.ResultsEleven out of 194 patients (5.6%) developed HF during follow-up (median: 1.0 years [0.8 - 1.5 years]). Even though basal glucose, fructosamine and glycated haemoglobin were significant predictive factors in the univariate analysis, after being adjusted by confounding variables and AGE they lost their statistical signification. Only AGE (Hazard Ratio 1.016, IC 95%: 1.006-1.026; p<0,001), together with NT-proBNP and the infarct extension were predictors for post-infarction HF development, where AGE levels over the median value 5-fold increased the risk of HF development during follow-up.ConclusionsAGE are an independent marker of post-infarction HF development risk.
PB BMC
SN 1475-2840
YR 2012
FD 2012
LK http://hdl.handle.net/10347/23081
UL http://hdl.handle.net/10347/23081
LA eng
NO Raposeiras-Roubín, S., Rodiño-Janeiro, B.K., Paradela-Dobarro, B. et al. Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report. Cardiovasc Diabetol 11, 102 (2012). https://doi.org/10.1186/1475-2840-11-102
NO This study was supported in part by the Plan Nacional Español de I+D, 2008–2011 and the Instituto de Salud Carlos III – Subdirección General de Evaluación y Fomento de la Investigación, PI10/01403, cofinanced by ERDF. The Isidro Parga Pondal program of the Xunta de Galicia (Spain) supported the work of E. Álvarez
DS Minerva
RD 24 abr 2026