RT Journal Article
T1 Gold(I)-Catalyzed Intermolecular Cycloaddition of Allenamides with α,β-Unsaturated Hydrazones: Efficient Access to Highly Substituted Cyclobutanes
A1 Bernal Albert, Paloma
A1 Faustino, Hélio
A1 Gimeno, Ana
A1 Asensio, Gregorio
A1 Mascareñas Cid, José Luis
A1 López García, Fernando
K1 Gold
K1 Catalysis
K1 Cycloaddition
K1 Allenamides
K1 Cyclobutanes
K1 Hydrazones
AB α,β-Unsaturated N,N-dialkyl hydrazones undergo a mild [2 + 2] cycloaddition to allenamides when treated with a suitable gold catalyst. The method, which represents the first application of N,N-dialkyl hydrazones in gold catalysis, iscompatible with a wide variety of substituents at the alkenyl moiety of the hydrazone component, proceeds with excellent levels of regio- and diastereoselectivity, and provides densely substituted cyclobutanes with good to excellent yields
PB American Chemical Society
SN 1523-7060
YR 2014
FD 2014-11-19
LK http://hdl.handle.net/10347/12379
UL http://hdl.handle.net/10347/12379
LA eng
NO Bernal-Albert, P., Faustino, H., Gimeno, A., Asensio, G., Mascareñas, J.L. and López, F. (2014). Gold(I)-Catalyzed Intermolecular Cycloaddition of Allenamides with α,β-Unsaturated Hydrazones: Efficient Access to Highly Substituted Cyclobutanes. Org. Lett., 2014,16 (23), pp. 6196–6199. doi: 10.1021/ol503121q
NO This work was supported by the Spanish MINECO (SAF2013-41943-R and FPI to P.B.A.), the ERDF, the European ResearchCouncil (Adv. Grant No. 340055), and the Xunta de Galicia (GRC2013-041). We thank the Orfeo-Cinqa network
DS Minerva
RD 24 abr 2026