RT Journal Article
T1 Amyloid-β Seeds in Alzheimer's disease: research challenges and implications
A1 Beschorner, Natalie
A1 Xu, Ying
A1 Jucker, Mathias
A1 Ruiz Riquelme, Alejandro
K1 Alzheimer's disease
K1 Amyloid beta
K1 Neurodegeneration
K1 Prion
K1 Seeding
AB The amyloid cascade hypothesis, proposed over 30 years ago, places amyloid-β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Though controversial, recent clinical successes with Aβ-targeting therapies have reinforced its importance. However, these treatments have shown only modest clinical benefits in line with a two-stage AD progression: an early phase driven by Aβ-seed and a later phase that progresses at least partly independently of Aβ. Evidence of Aβ seed transmission in humans raises both therapeutic potential and biosafety concerns. This review explores current understanding of Aβ seeds, including challenges in studying such seeds, model systems to study Aβ seeds, and biosafety issues when working with Aβ seeds
PB Wiley
SN 0022-3042
YR 2025
FD 2025-11-03
LK https://hdl.handle.net/10347/43547
UL https://hdl.handle.net/10347/43547
LA eng
NO Beschorner, N., Y. Xu, M. Jucker, and A. Ruiz-Riquelme. 2025. “ Amyloid-β Seeds in Alzheimer's Disease: Research Challenges and Implications.” Journal of Neurochemistry 169, no. 11: e70267. https://doi.org/10.1111/jnc.70267
DS Minerva
RD 23 abr 2026