RT Journal Article
T1 Determination of synthetic opioids in oral fluid samples using fabric phase sorptive extraction and gas chromatography-mass spectrometry
A1 Ares Fuentes, Ana María
A1 Lorenzo Ferreira, Rosa Antonia
A1 Fernández Gómez, Purificación
A1 Fernández, Ana María
A1 Furton, Kenneth G.
A1 Kabir, Abuzar
A1 Carro Díaz, Antonia María
K1 Fentanyl
K1 Fabric phase sorptive extraction (FPSE)
K1 Gas chromatography-mass spectrometry (GC-MS)
K1 Oral fluid
K1 Synthetic opioids
AB New psychoactive substances (NPS) continue to emerge in the drug market every year, becoming a global threat to public health and safety. These compounds are mostly synthetic cannabinoids and designer cathinones. However, synthetic opioids have appeared on the recreational drug markets in recent years, particularly fentanyl and its derivatives (“fentanyls”). Fentanyl and its analogs are related to harmful intoxications and an increase in opioid-related mortality in many countries, such as in the United States and Europe in the last years. Taking the drug related global crisis into consideration, this work developed and validated an effective and sensitive method based on fabric phase sorptive extraction (FPSE) followed by gas chromatography-mass spectrometry (GC-MS) for the simultaneous determination of 11 fentanyl analogs in oral fluid samples. The extraction was carried out using a sol-gel Carbowax 20 M sorbent immobilized on 100% cellulose fabric substrate and using ethyl acetate as the desorption solvent. The limits of detection (LODs) and quantification (LOQs) ranged from 1 to 15 ng mL−1 and 5 to 50 ng mL−1, respectively. Intra-day and inter-day precision were found within 8.2% and 8.6%, respectively, while accuracy ranged from -5.5 to 9.1%, in accordance with the established criteria. The absolute recovery values were in the range of 94.5%–109.1%. The validated method demonstrated its great potential to detect and quantify fentanyl analogs in possible forensic work and off-site analysis in road traffic cases
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/27900
UL http://hdl.handle.net/10347/27900
LA eng
NO Journal of Chromatography A 1663 (2022) 462768. https://doi.org/10.1016/j.chroma.2021.462768
NO This work was supported by the Spanish Ministry of Science, Innovation, and Universities (Project RTI2018‐096450‐B‐I00) and FEDER funds
DS Minerva
RD 24 abr 2026