RT Journal Article
T1 Rotavirus intestinal infection induces an oral mucosa cytokine response
A1 Gómez Rial, José
A1 Currás Tuala, María José
A1 Rivero Calle, Irene
A1 Rodríguez-Tenreiro Sánchez, Carmen
A1 Redondo-Collazo, Lorenzo
A1 Gómez Carballa, Alberto
A1 Pardo Seco, Jacobo José
A1 Salas Ellacuriaga, Antonio
A1 Martinón Torres, Federico
AB IntroductionSalivary glands are known immune effector sites and considered to be part of the whole mucosal immune system. The aim of the present study was to assess the salivary immune response to rotavirus (RV) infection through the analysis of the cytokine immune profile in saliva.Material and methodsA prospective comparative study of serial saliva samples from 27 RV-infected patients (sampled upon admission to the hospital during acute phase and at convalescence—i.e. at least three months after recovery) and 36 healthy controls was performed. Concentrations of 11 salivary cytokines (IFN-γ, IFN-α2, IL-1β, IL-6, IL-8, IL-10, IL-15, IL12p70, TNF-α, IFN-λ1, IL-22) were determined. Cytokine levels were compared between healthy controls acute infection and convalescence. The correlation between clinical data and salivary cytokine profile in infected children was assessed.ResultsThe salivary cytokine profile changes significantly in response to acute RV infection. In RV-infected patients, IL-22 levels were increased in the acute phase with respect to convalescence (P-value < 0.001). Comparisons between infected and control group showed significant differences in salivary IFN-α2, IL-1β, IL-6, IL-8, IL-10 and IL-22. Although acute-phase levels of IL-12, IL-10, IL-6 and IFN-γ showed nominal association with Vesikari’s severity, this trend did not reach statistical significance after multiple test adjustment.ConclusionsRV infection induces a host salivary immune response, indicating that immune mucosal response to RV infection is not confined to the intestinal mucosa. Our data point to a whole mucosal implication in the RV infection as a result of the integrative mucosal immune response, and suggest the salivary gland as effector site for RV infection.
PB PLOS
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22809
UL http://hdl.handle.net/10347/22809
LA eng
NO Gómez-Rial J, Curras-Tuala MJ, Rivero-Calle I, Rodríguez-Tenreiro C, Redondo-Collazo L, Gómez-Carballa A, et al. (2018) Rotavirus intestinal infection induces an oral mucosa cytokine response. PLoS ONE 13(4): e0195314. https://doi.org/10.1371/journal.pone.0195314
NO This study received support from the Instituto de Salud Carlos III (Proyecto de Investigación en Salud, Acción Estratégica en Salud): project GePEM ISCIII/PI16/01478/Cofinanciado FEDER (A.S.) and project ReSVinext ISCIII/PI16/01569/Cofinanciado FEDER (F.M.T.); Consellería de Sanidade, Xunta de Galicia (RHI07/2-intensificación de la actividad investigadora, PS09749 and 10PXIB918184PR), Instituto de Salud Carlos III (Intensificación de la actividad investigadora 2007–2012, PI16/01569), Fondo de Investigación Sanitaria (FIS; PI070069/PI1000540) del Plan Nacional de I + D + I and ‘fondos FEDER’ (F.M.T.), and 2016-PG071 Consolidación e Estructuración REDES 2016GI-1344 (from Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia) G3VIP (Grupo Gallego de Genética Vacunas Infecciones y Pediatría, ED341D R2016/021) (A.S. and F.M.T) and funding from Merck Sharp and Dohme
DS Minerva
RD 24 abr 2026