RT Journal Article
T1 Iron Deposits in Periaqueductal Gray Matter Are Associated with Poor Response to OnabotulinumtoxinA in Chronic Migraine
A1 Domínguez Vivero, Clara
A1 Leira Feijóo, Yago
A1 Saavedra Piñeiro, Marta
A1 Rodríguez Osorio, Xiana
A1 Ramos Cabrer, Pedro
A1 Villalba Martín, Carmen
A1 Sobrino Moreiras, Tomás
A1 Campos Pérez, Francisco
A1 Castillo Sánchez, José Antonio
A1 Leira Muiño, Rogelio Manuel
K1 Periaqueductal gray matter
K1 Iron deposits
K1 OnabotulinumtoxinA
K1 Chronic migraine
AB Previous studies have reported increased brain deposits of iron in patients with chronic migraine (CM). This study aims to determine the relation between iron deposits and outcome after treatment with OnabotulinumtoxinA (OnabotA). Demographic and clinical data were collected for this study through a prospective cohort study including 62 CM patients treated with OnabotA in the Hospital Clínico Universitario de Santiago de Compostela (Spain). Demographic and clinical variables were registered. Selected biomarkers in plasma during interictal periods (calcitonin gene-related peptide (CGRP) and pentraxin-3 (PTX3)) and neuroimaging changes (iron deposits in the red nucleus (RN), substantia nigra (SN), globus pallidus (GP), and periaqueductal gray matter (PAG), and white matter lesions (WML)) were determined. Subjects were classified in responders (≥50% reduction in headache days) or non-responders (<50%). Responders to treatment were younger (mean age difference = 12.2; 95% confidence interval (CI): 5.4–18.9, p = 0.001), showed higher serum levels of CGRP (≥50 ng/mL) and PTX3 (≥1000 pg/mL) and smaller iron deposits in the GP and PAG (mean difference = 805.0; 95% CI: 37.9–1572.1 μL, p = 0.040 and mean difference = 69.8; 95% CI: 31.0–108.6 μL, p = 0.008; respectively). Differences in PAG iron deposits remained significant after adjusting for age (mean difference = 65.7; 95% CI: 22.8–108.6 μL, p = 0.003) and were associated with poor response to OnabotA after adjustment for clinical and biochemical variables (odds ratio (OR) = 0.963; 95% CI: 0.927–0.997, p = 0.041). We conclude that larger PAG iron deposits are associated with poor response to OnabotA in CM
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23599
UL http://hdl.handle.net/10347/23599
LA eng
NO Domínguez Vivero, C.; Leira, Y.; Saavedra Piñeiro, M.; Rodríguez-Osorio, X.; Ramos-Cabrer, P.; Villalba Martín, C.; Sobrino, T.; Campos, F.; Castillo, J.; Leira, R. Iron Deposits in Periaqueductal Gray Matter Are Associated with Poor Response to OnabotulinumtoxinA in Chronic Migraine. Toxins 2020, 12, 479
NO Spanish Ministry of Economy and Competitiveness—Institute of Health Carlos III, grant/award number PI15/01578
DS Minerva
RD 28 abr 2026