RT Journal Article
T1 Dissecting genetic effects with imprinting
A1 Álvarez Castro, José María
K1 Imprinting
K1 Individual-referenced models of genetic effects
K1 Population-referenced models of genetic effects
K1 NOIA
K1 Genetic variance decomposition
AB Models of genetic effects are mathematical representations of a genotype-to-phenotype (GP) map that, rather than accounting for a raw map assigning phenotypes to genotypes, rely on parameters with deliberate evolutionary meaning—additive and interaction effects. In this article, the conceptual particularities of genetic imprinting and their implications on models of genetic effects are analyzed. The molecular mechanisms by which imprinted loci affect the relationship between genotypes and phenotypes are known to be singular. Despite its epigenetic nature, the (parent-of-origin-dependent) way in which the alleles of imprinted genes are modified and segregate in each generation is precisely determined, and thus amenable to be represented through conventional models of genetic effects. The Natural and Orthogonal Interactions (NOIA) model framework is here extended to account for imprinting as a tool for a more thorough analysis of the evolutionary implications of this phenomenon. The resulting theory improves and generalizes previous proposals for modeling imprinting.
PB Frontiers Media
YR 2014
FD 2014
LK http://hdl.handle.net/10347/22823
UL http://hdl.handle.net/10347/22823
LA eng
NO Álvarez-Castro JM (2014) Dissecting genetic effects with imprinting. Front. Ecol. Evol. 2:51. doi: 10.3389/fevo.2014.00051
NO The Autonomous Administration Xunta de Galicia provided funding for this research through project EM2014/024
DS Minerva
RD 26 abr 2026