RT Journal Article
T1 Demographic and topographic fndings suggesting poor response to crosslinking‑iontophoresis in patients with progressive keratoconus
A1 Touriño Peralba, Rosario
A1 Rodríguez Lago, Julio
A1 Lamas Francis, David
A1 Martínez Pérez, Laura
A1 Rodríguez Ares, María Teresa
K1 Keratoconus
K1 Cross-linking
K1 Iontophoresis
K1 Transepithelial
K1 Tomography
AB Purpose: To evaluate demographic and tomographical parameters in predicting treatment response following transepithelial iontophoresis-assisted corneal cross-linking (I-CXL) for progressive keratoconus.Methods: Forty eyes (20 aged<19  years and 20 aged≥19 years) underwent I-CXL treatment between 2016 and 2022. Progression criteria based on theABCD system, changes in asphericity (Q), demographic factors and keratoconus phenotypes were evaluated. Subjects were followed for 24 months after procedure.Results: Sixty percent of participants were male. The mean age at the time of treatment was 21.0±6.0  years. All tomographical values showedprogression after 2 years of follow-up (p<0.05), particularly during the frst 6 months, except for anterior curvature. Within the ABCD grading system, we observed: A) an increase in anterior curvature, more evident with lower initial values; B) an increase in posterior curvature, more pronounced with higher initial values. Two years after I-CXL, 20% of subjects met progression criteria in two or more parameters, with 62.5% being under 19 years of age. Patients with a family history of corneal ectasia exhibited a mean KMax progression of 1.94D±1.88, (p=0.046). Only phenotypes 3 and 4 showed progression. Although patients under 19  years showed greater progression in all tomographical variables at the end of the study, this diference was not statistically signifcant.Conclusion: Treatment with I-CXL did not stop progression in the variables studied two years after the procedure in an efective manner, especially inpatients younger than 19  years. A family history of corneal ectasia and subtype 4 keratoconus predicted a less favourable response to I-CXL.
PB Springer
SN 0165-5701
YR 2025
FD 2025-02-10
LK https://hdl.handle.net/10347/42257
UL https://hdl.handle.net/10347/42257
LA eng
NO Touriño-Peralba, R., Rodríguez-Lago, J., Lamas-Francis, D. et al. Demographic and topographic findings suggesting poor response to crosslinking-iontophoresis in patients with progressive keratoconus. Int Ophthalmol 45, 69 (2025). https://doi.org/10.1007/s10792-025-03421-9
NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.
DS Minerva
RD 3 may 2026