RT Journal Article
T1 Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
A1 Othman, Haifa
A1 López Furelos, Alberto
A1 Leiro Vidal, José Manuel
A1 Ammari, Mohamed
A1 Sakly, Mohsen
A1 Abdelmelek, Hafedh
A1 Salas Sánchez, Aarón Ángel
A1 Ares Pena, Francisco José
A1 López Martín, María Elena
K1 2.45 GHz radiation
K1 GFAP
K1 Glucocorticoid receptor
K1 HSP-70
K1 Nonionizing radiation
AB Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating induction of heat shock protein 70 (HSP-70), glucocorticoid receptors (GCR) or glial fibrillary acidic protein (GFAP) after single or repeated exposure to 2.45 GHz radiation in the experimental set-up. Neither radiation regime caused tissue heating, so thermal effects can be ruled out. A progressive decrease in GCR and HSP-70 was observed after acute or repeated irradiation in the somatosensory cortex, hypothalamus and hippocampus. In the limbic cortex; however, values for both biomarkers were significantly higher after repeated exposure to irradiation when compared to control animals. GFAP values in brain tissue after irradiation were not significantly different or were even lower than those of nonirradiated animals in all brain regions studied. Our results suggest that repeated exposure to 2.45 GHz elicited GCR/HSP-70 dysregulation in the brain, triggering a state of stress that could decrease tissue anti-inflammatory action without favoring glial proliferation and make the nervous system more vulnerable
PB MDPI
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26235
UL http://hdl.handle.net/10347/26235
LA eng
NO Int. J. Mol. Sci. 2021, 22(10), 5103; https://doi.org/10.3390/ijms22105103
NO This work was supported in part by the FEDER/Ministerio de Ciencia, Innovación y Universidades-Agencia Estatal de Investigación under Project TEC2017-86110-R. The work of A.Á.S.-S. is supported by the Xunta de Galicia Postdoctoral Fellowship, reference ED481B 2018/008. The financial support of the Tunisian Ministry of Higher Education and Scientific Research is gratefully acknowledged
DS Minerva
RD 27 abr 2026