RT Journal Article
T1 An LC-MS/MS methodological approach to analysis of hair for amphetamine-type-stimulant (ATS) drugs, including selected synthetic cathinones and piperazines
A1 Lendoiro Belío, Elena
A1 Jiménez-Morigosa, Cristian
A1 Cruz Landeira, Angelines
A1 Páramo, Mario
A1 López-Rivadulla Lamas, Manuel
A1 Castro Ríos, Ana de
K1 Hair
K1 Amphetamine-type-stimulants
K1 New psychoactive substances
K1 Synthetic cathinones
K1 Synthetic piperazines
AB Drug exposure during pregnancy constitutes a major legal issue and a public health concern. Drug and metabolite determination in biological matrices from mother and newborn is an objective indication of prenatal drug exposure. However, limited data are available regarding the interpretation of these analytical results in terms of window of detection and degree of exposure. We collected paired maternal hair, meconium, placenta, and umbilical cord from 727 mother-newborn dyads. We analyzed these specimens by liquid chromatography-tandem mass spectrometry for the determination of cocaine, opioids, methadone, and amphetamines, and compared the analytical results from the four different matrices. The cases were divided in non-exposure, low, and frequent exposure, based on maternal hair concentrations and segmental analysis by trimesters. For cocaine, 62 cases tested positive in hair, 9 in meconium, 6 in placenta and 7 in umbilical cord. In the case of opioids, 14 maternal hair cases were positive, 11 meconium and umbilical cord and 9 placenta samples. For methadone, 11 cases were positive in hair, 9 in meconium and 6 in placenta and umbilical cord. For amphetamines, 18 cases were positive according to maternal hair, but all meconium, placenta, and umbilical cord tested negative. Maternal hair was the most sensitive specimen to detect drug exposure during pregnancy. Meconium, placenta, and umbilical cord tested positive if hair concentrations showed frequent drug use during the whole pregnancy, especially during the third trimester. Meconium, placenta, and umbilical cord also tested positive for morphine and metabolites, if this drug was administered during labour and delivery.
PB Wiley
SN 1942-7603
YR 2017
FD 2017
LK https://hdl.handle.net/10347/38896
UL https://hdl.handle.net/10347/38896
LA eng
NO Elena Lendoiro; Cristian Jiménez-Morigosa; Angelines Cruz; Manuel López-Rivadulla; Ana de Castro. An LC-MS/MS methodological approach to analysis of hair for amphetamine-type-stimulant (ATS) drugs, including selected synthetic cathinones and piperazines. Drug Test Anal. 2017;9(1):96-105
NO This is the peer reviewed version of the following article: [Elena Lendoiro; Cristian Jiménez-Morigosa; Angelines Cruz; Manuel López-Rivadulla; Ana de Castro. An LC-MS/MS methodological approach to analysis of hair for amphetamine-type-stimulant (ATS) drugs, including selected synthetic cathinones and piperazines. Drug Test Anal. 2017;9(1):96-105], which has been published in final form at https://doi.org/10.1002/dta.1948. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
NO E. Lendoiro and A. de Castro would like to thank Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, for their predoctoral (PRE/2011/072), and post-doctoral (POS-B/2013/003) contracts, respectively.
DS Minerva
RD 28 abr 2026