RT Journal Article
T1 Human salivary microRNAs in Cancer
A1 Rapado González, Óscar
A1 Majem, Blanca
A1 Muinelo Romay, Laura
A1 Álvarez Castro, Ana
A1 Santamaría, Anna
A1 Gil Moreno, Antonio
A1 López López, Rafael
A1 Suárez Cunqueiro, María Mercedes
K1 miRNAs
K1 Saliva
K1 Cancer
K1 Normalization
K1 Biomarkers
K1 Liquid biopsy
AB Circulating microRNAs (miRNAs) have emerged as excellent candidates for cancer biomarkers. Several recent studies have highlighted the potential use of saliva for the identification of miRNAs as novel biomarkers, which represents a great opportunity to improve diagnosis and monitor general health and disease. This review summarises the mechanisms of miRNAs deregulation in cancer, the value of targeting them with a therapeutic intention and the evidence of the potential clinical use of miRNAs expressed in saliva for the detection of different cancer types. We also provide a comprehensive review of the different methods for normalising the levels of specific miRNAs present in saliva, as this is a critical step in their analysis, and the challenge to validate salivary miRNAs as a reality to manage cancer patients
PB Ivyspring International Publisher
YR 2018
FD 2018-01-06
LK http://hdl.handle.net/10347/16800
UL http://hdl.handle.net/10347/16800
LA eng
NO Rapado-González Ó, Majem B, Muinelo-Romay L, Álvarez-Castro A, Santamaría A, Gil-Moreno A, López-López R, Suárez-Cunqueiro MM. Human salivary microRNAs in Cancer. J Cancer 2018; 9(4):638-649. doi:10.7150/jca.21180
NO The authors would like to thank the Eugenio Rodríguez Pascual Foundation and the Fundación Dexeus Salud de la Mujer, for supporting the authors’ studies in the field of salivary biomarkers
DS Minerva
RD 26 abr 2026