RT Journal Article T1 Decoding the Role of Gut-Microbiome in the Food Addiction Paradigm A1 Garrido Novelle, Marta K1 Food addiction K1 Eating behaviour K1 Reward K1 Obesity K1 Gut-microbiome K1 Gut-dysbiosis AB Eating behaviour is characterised by a solid balance between homeostatic and hedonic regulatory mechanisms at the central level and highly influenced by peripheral signals. Among these signals, those generated by the gut microbiota have achieved relevance in recent years. Despite this complex regulation, under certain circumstances eating behaviour can be deregulated becoming addictive. Although there is still an ongoing debate about the food addiction concept, studies agree that patients with eating addictive behaviour present similar symptoms to those experienced by drug addicts, by affecting central areas involved in the control of motivated behaviour. In this context, this review tries to summarise the main data regarding the role of the gut microbiome in eating behaviour and how a gut dysbiosis can be responsible for a maladaptive behaviour such as “food addiction” PB MDPI YR 2021 FD 2021 LK http://hdl.handle.net/10347/26732 UL http://hdl.handle.net/10347/26732 LA eng NO Int. J. Environ. Res. Public Health 2021, 18(13), 6825; https://doi.org/10.3390/ijerph18136825 NO Financial support from the Xunta de Galicia (Centro singular de investigación de Galicia accreditation 2019-2022- ED431G 2019/02) and the European Union (European Regional Development Fund-ERDF) is gratefully acknowledged. Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn) is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain, which is supported by ERDF funds. MGN is recipient of “Juan de la Cierva-Incorporación” fellowship (IJCI-2017-32606) from Ministerio de Ciencia, Innovación y Universidades, Spain DS Minerva RD 28 abr 2026