RT Journal Article
T1 Targeting joint inflammation for osteoarthritis management through stimulus-sensitive hyaluronic acid based intra-articular hydrogels
A1 Díaz Rodríguez, Patricia
A1 Mariño Lijó, Cibrán
A1 Vázquez, José Antonio
A1 Caeiro Rey, José Ramón
A1 Landín Pérez, Mariana
K1 Hyaluronic acid
K1 Intra-articular hydrogels
K1 Thermo-sensitive systems
K1 Anti-inflammatory activity
K1 Osteoarthritis
AB Numerous therapeutic strategies have been developed for osteoarthritis (OA) management, including intra-articular (IA) injections. The ideal IA formulation should control cartilage degradation and restore synovial fluid viscosity. To this end, we propose to combine thermo-sensitive polymers (poloxamers) with hyaluronic acid (HA) to develop suitable beta-lapachone (βLap) loaded IA formulations. The development of IA formulations with these components entails several difficulties: low βLap solubility, unknown βLap therapeutic dose and the bonded commitment of easy administration and viscosupplementation. An optimized formulation was designed using artificial intelligence tools based on the experimental results of a wide variety of hydrogels and its therapeutic capacity was evaluated on an ex vivo OA model. The formulation presented excellent rheological properties and significantly decreased the secretion of degradative (MMP13) and pro-inflammatory (CXCL8) molecules. Therefore, the developed formulation is a promising candidate for OA treatment restoring the synovial fluid rheological properties while decreasing inflammation and cartilage degradation
PB Elsevier
SN 0928-4931
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26730
UL http://hdl.handle.net/10347/26730
LA eng
NO Materials Science and Engineering: C 2021, 128: 112254. https://doi.org/10.1016/j.msec.2021.112254
NO Financial support was received from Interreg V-A POCTEP (0245_IBEROS_1_E) EU (FEDER). Research groups are also supported by Xunta de Galicia (Competitive Reference Groups, ED431C 2020/17-FEDER) and (Grupos de Potencial Crecimiento, IN607B 2018/19-FEDER)
DS Minerva
RD 26 abr 2026