RT Journal Article
T1 Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles
A1 Comas, Laura
A1 Polo Tobajas, Ester
A1 Domingo, M. Pilar
A1 Hernández, Yulán
A1 Arias, Maykel
A1 Esteban, Patricia
A1 Martínez-Lostao, Luis
A1 Pardo, Julián
A1 Martínez de la Fuente, Jesús
A1 Gálvez, Eva M.
K1 Magnetic nanoparticles
K1 Gliotoxin
K1 Therapeutic
K1 Drug delivery
K1 Cancer cells
AB Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer
PB MDPI
SN 1996-1944
YR 2019
FD 2019
LK http://hdl.handle.net/10347/19757
UL http://hdl.handle.net/10347/19757
LA eng
NO Comas, L.; Polo, E.; Domingo, M.P.; Hernández, Y.; Arias, M.; Esteban, P.; Martínez-Lostao, L.; Pardo, J.; Martínez de la Fuente, J.; Gálvez, E.M. Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles. Materials 2019, 12, 1092
NO This work was supported by Fondo Social Europeo (FSE; Gobierno de Aragón), ASPANOA and by grants SAF2017-83120-C2-1-R, SAF2014-54763-C2-1-R, SAF2014-54763-C2-2-R from Spanish Ministry of Economy and Competitivenes. LC was granted by a DGA predoctoral contract, EP by a Juan de la Cierva Incorporacion fellowship program (IJCI-2016-30706) and MA by a Juan de la Cierva Formación fellowship program (FJCI-2017-31629)
DS Minerva
RD 7 jun 2026