RT Journal Article
T1 Transition Metal‐Promoted Reactions in Aqueous Media and Biological Settings
A1 Destito, Paolo
A1 Vidal Vides, Cristian
A1 López García, Fernando
A1 Mascareñas Cid, José Luis
K1 Aqueous catalysis
K1 Biocatalysis
K1 Biological chemistry
K1 Cellular chemistry
K1 Organometallic catalysis
AB During the last decade, there has been a tremendous interest for developing non‐natural biocompatible transformations in biologically relevant media. Among the different encountered strategies, the use of transition metal complexes offers unique possibilities due to their high transformative power. However, translating the potential of metal catalysts to biological settings, including living cells or small‐animal models such as mice or zebrafish, poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments. Herein, we describe the most relevant advances in this direction, with a particular emphasis on the systems’ structure, their mode of action and the mechanistic bases of each transformation. Thus, the key challenges from an organometallic perspective might be more easily identified
PB Wiley
YR 2021
FD 2021
LK http://hdl.handle.net/10347/24848
UL http://hdl.handle.net/10347/24848
LA eng
NO Destito, P.; Vidal, C.; and López, F.; Mascareñas, J. L. (2021), Transition Metal- Promoted Reactions in Aqueous Media and Biological Settings. Chem. Eur. J., 27: 4789-4816. doi: 10.1002/chem.202003927
NO This is the peer reviewed version of the following article: P. Destito, C. Vidal, F. López, J. L. Mascareñas, Chem. Eur. J. 2021, 27, 4789, which has been published in final form at https://doi.org/10.1002/chem.202003927. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
NO We would like to acknowledge financial support from Spanish grants (SAF2016‐76689‐R, CTQ2017‐84767‐P and ORFEO‐CINQA network CTQ2016‐81797‐REDC), the Consellería de Cultura, Educación e Ordenación Universitaria (2015‐CP082, ED431C‐2017/19 and Centro Singular de Investigación de Galicia accreditation 2019–2022, ED431G 2019/03), the European Union (European Regional Development Fund‐ERDF corresponding to the multiannual financial framework 2014–2020), and the European Research Council (Advanced Grant No. 340055). D.F.F. thanks Xunta de Galicia for his postdoctoral fellowship (ED481B‐2019‐005)
DS Minerva
RD 30 abr 2026