RT Journal Article
T1 Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index
A1 Pardo Pérez, María
A1 Crujeiras Martínez, Ana Belén
A1 Amil Diz, María
A1 Agüera, Zaida
A1 Jiménez Murcia, Susana
A1 Baños, Rosa M.
A1 Botella, Cristina
A1 Torre, Rafael de la
A1 Estivill, Xavier
A1 Fagundo, Ana Beatriz
A1 Fernández Real, Jose M.
A1 Fernández García, José C.
A1 Fruhbeck, Gema
A1 Gómez Ambrosi, Javier
A1 Rodríguez, Roser
A1 Tinahones Madueño, Francisco José
A1 Fernández Aranda, Fernando
A1 Casanueva Freijo, Felipe
AB FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.
PB Hindawi
SN 1687-8337
YR 2014
FD 2014
LK http://hdl.handle.net/10347/22252
UL http://hdl.handle.net/10347/22252
LA eng
NO Pardo, M., Crujeiras, A., Amil, M., Aguera, Z., Jiménez-Murcia, S., & Baños, R. et al. (2014). Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index. International Journal Of Endocrinology, 2014, 1-9. https://doi.org/10.1155/2014/857270
NO The authors thank the volunteers for their participation in the study. This work was supported by CIBERobn (CB06/03), INTRASALUD Project (no. PI10/02464), and PI13/01915, Instituto de Salud Carlos III (ISCIII) initiatives. The study was also supported by Fondo de Investigación Sanitaria-FIS (PI11/210) and AGAUR (2009SGR1554). Ana B. Crujeiras is funded by the ISCIII through a research contract “Sara Borrell” (C09/00365). María Pardo is a Miguel Servet Fellow (ISCIII/SERGAS). Ana B. Fagundo is funded by Ministerio de Ciencia e Innovación Subprograma through a research contract Juan de la Cierva (JCI-2011-09248). José C. Fernández-García is recipient of a “Rio Hortega” contract from “Instituto de Salud Carlos III,” Madrid, Spain (CM12/00059)
DS Minerva
RD 4 may 2026