RT Journal Article
T1 Acute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX
A1 Fernández Ferreiro, Sara
A1 Carrera González, María Cristina
A1 Vilariño del Río, Natalia
A1 Louzao Ojeda, María del Carmen
A1 Santamarina Pernas, Germán
A1 González Cantalapiedra, Antonio
A1 Botana López, Luis Miguel
K1 Okadaic acid
K1 Dynophysistoxins
K1 Yessotoxin
K1 Cardiotoxicity
K1 hERG
K1 ECG
K1 Cardiac biomarkers
AB Phycotoxins are marine toxins produced by phytoplankton that can get accumulated in filter feeding shellfish. Human intoxication episodes occur due to contaminated seafood consumption. Okadaic acid (OA) and dynophysistoxins (DTXs) are phycotoxins responsible for a severe gastrointestinal syndrome called diarrheic shellfish poisoning (DSP). Yessotoxins (YTXs) are marine toxins initially included in the DSP class but currently classified as a separated group. Food safety authorities from several countries have regulated the content of DSPs and YTXs in shellfish to protect human health. In mice, OA and YTX have been associated with ultrastructural heart damage in vivo. Therefore, this study explored the potential of OA, DTX-1 and YTX to cause acute heart toxicity. Cardiotoxicity was evaluated in vitro by measuring hERG (human èter-a-go-go gene) channel activity and in vivo using electrocardiogram (ECG) recordings and cardiac damage biomarkers. The results demonstrated that these toxins do not exert acute effects on hERG channel activity. Additionally, in vivo experiments showed that these compounds do not alter cardiac biomarkers and ECG in rats acutely. Despite the ultrastructural damage to the heart reported for these toxins, no acute alterations of heart function have been detected in vivo, suggesting a functional compensation in the short term
PB MDPI
YR 2015
FD 2015
LK http://hdl.handle.net/10347/23591
UL http://hdl.handle.net/10347/23591
LA eng
NO Ferreiro, S.F.; Carrera, C.; Vilariño, N.; Louzao, M.C.; Santamarina, G.; Cantalapiedra, A.G.; Botana, L.M. Acute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX. Toxins 2015, 7, 1030-1047
NO The research leading to these results has received funding from the following FEDER cofunded-grants. From CDTI and Technological Funds, supported by Ministerio de Economía y Competitividad, AGL2012-40185-CO2-01 and Consellería de Cultura, Educación e Ordenación Universitaria, GRC2013-016, and through Axencia Galega de Innovación, Spain, ITC-20133020 SINTOX, IN852A 2013/16-3 MYTIGAL. From CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD.From the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency (FP7/2007–2013) under grant agreement Nos. 265409 µAQUA, 315285 CIGUATOOLS and 312184 PHARMASEA
DS Minerva
RD 28 abr 2026