RT Journal Article
T1 ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents
A1 Barja Fernández, Silvia
A1 Folgueira Cobos, Cintia
A1 Castelao Taboada, Cecilia
A1 Pena León, Verónica
A1 González Saenz, Patricia
A1 Vázquez Cobela, Rocío
A1 Aguilera, Concepción M.
A1 Gil Campos, Mercedes
A1 Bueno Lozano, Gloria
A1 Gil, Ángel
A1 Moreno, Luis A.
A1 Ruiz Piñón, Manuel
A1 García Palacios, María
A1 Casanueva Freijo, Felipe
A1 Diéguez González, Carlos
A1 Nogueiras Pozo, Rubén
A1 Leis Trabazo, María Rosaura
A1 Seoane Camino, Luisa María
K1 ANGPTL-4
K1 BMI loss
K1 Childhood
K1 Lipid profile
K1 Obesity
AB Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3–17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5–18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/23875
UL http://hdl.handle.net/10347/23875
LA eng
NO Barja-Fernández, S.; Folgueira, C.; Castelao, C.; Pena-León, V.; González-Saenz, P.; Vázquez-Cobela, R.; Aguilera, C.M.; Gil-Campos, M.; Bueno, G.; Gil, Á.; Moreno, L.A.; Ruiz-Piñon, M.; García-Palacios, M.; Casanueva, F.F.; Diéguez, C.; Nogueiras, R.; Leis, R.; Seoane, L.M. ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. Nutrients 2019, 11, 1340
NO This research was funded by INSTITUTO DE SALUD CARLOS III cofounded by FEDER, grants number PI18/00998, PI15/01272, PI11/02042, PI16/01301, and PI16/00871, and FUNDACIÓN MUTUA MADRILEÑA
DS Minerva
RD 28 abr 2026