RT Journal Article
T1 Exosomal ncRNAs in reproductive cancers
A1 Kowalczyk, Alicja
A1 Wrzecińska, Marcjanna
A1 Gałȩska, Elzbieta
A1 Czerniawska-Piątkowska, Ewa
A1 Camiña García, María Mercedes
A1 Araujo, Jose P.
A1 Dobrzański, Zbigniew
K1 Cancers
K1 Exosomes
K1 Extracellular vesicles
K1 MicroRNA
K1 Reproduction
K1 Reproductive cancers
AB Extracellular vesicles, particularly exosomes, play a pivotal role in the cellular mechanisms underlying cancer. This review explores the various functions of exosomes in the progression, growth, and metastasis of cancers affecting the male and female reproductive systems. Exosomes are identified as key mediators in intercellular communication, capable of transferring bioactive molecules such as microRNAs, proteins, and other nucleic acids that influence cancer cell behavior and tumor microenvironment interactions. It has been shown that non-coding RNAs transported by exosomes play an important role in tumor growth processes. Significant molecules that may serve as biomarkers in the development and progression of male reproductive cancers include miR-125a-5p, miR-21, miR-375, the miR-371 ∼ 373 cluster, and miR-145-5p. For female reproductive cancers, significant microRNAs include miR-26a-5p, miR-148b, miR-205, and miRNA-423-3p. This review highlights the potential of these noncoding RNAs as biomarkers and prognostics in tumor diagnostics. Understanding the diverse roles of exosomes may hold promise for developing new therapeutic strategies and improving treatment outcomes for cancer patients.
PB Oxford University Press
YR 2025
FD 2025
LK https://hdl.handle.net/10347/45814
UL https://hdl.handle.net/10347/45814
LA eng
NO Kowalczyk, A., Wrzecińska, M., Gałȩska, E., Czerniawska-Piątkowska, E., Camiña, M., Araujo, J. P., & Dobrzański, Z. (2025). Exosomal ncRNAs in reproductive cancers [Review of Exosomal ncRNAs in reproductive cancers]. Biology of Reproduction, 112(2), 225-244. Oxford University Press. https://doi.org/10.1093/BIOLRE/IOAE170
DS Minerva
RD 21 may 2026