RT Dissertation/Thesis
T1 Quorum sensing and oral biofilm: an alternative for the prevention and treatment of oral diseases
A1 Parga Martínez, Ana
K1 quorum sensing
K1 quorum quenching
K1 AHLs
K1 oral microbiology
K1 oral biofilm
K1 oral diseases
AB The present thesis investigates the potential of inhibiting bacterial cell-cellcommunication, quorum sensing (QS), to modulate oral biofilm formation. The thesis evaluates the effect of aquorum quenching (QQ) enzyme that degrades N-acylhomoserine lactones, the QS signals of gram-negativebacteria, on in vitro polymicrobial oral biofilms. The potential interactions between AHLs and a gram-positiverepresentative, Enterococcus faecalis, were also investigated. The results presented here support the translation ofQQ strategies to in vivo trials for the modulation of oral biofilms. In addition, a more intricate role of AHLs on oralbiofilm formation and interactions with gram-positive bacteria is proposed.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30338
UL http://hdl.handle.net/10347/30338
LA eng
DS Minerva
RD 29 abr 2026