RT Journal Article
T1 Determination of 18 organophosphorus flame retardants/plasticizers in mussel samples by matrix solid-phase dispersion combined to liquid chromatography-tandem mass spectrometry
A1 Castro Bustelo, Verónica
A1 Montes Goyanes, Rosa
A1 Quintana Álvarez, José Benito
A1 Rodil Rodríguez, María del Rosario
A1 Cela Torrijos, Rafael
K1 Sample preparation
K1 Organophosphate esters
K1 Marine biota
K1 Mollusc bivalves
AB This study presents the development and validation of a new analytical method based on matrix solid-phase dispersion (MSPD), integrating sample extraction and clean-up in one single step, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of 18 organophosphorus flame retardants and/or plasticizers (OPEs) in marine mussel (Mytilus edulis and Mytilus galloprovincialis) samples. Among these OPEs, 5 (tetraethyl 1,2-ethanediylbis(phosphonate), 6H-dibenzo[c,e] [1,2]oxaphosphinine 6-oxide, tris(2,3-dibromopropyl) phosphate, 2,2-propanediyldi-4,1-phenylene bis(phosphate) and resorcinol bis(diphenyl phosphate)) are considered here for the first time in marine samples. Different parameters affecting the MSPD (clean-up sorbent and elution solvent) were optimized to obtain a good compromise between analyte recoveries and extract clean-up. Also, particular attention was paid to tackle blank issues. The overall method was validated in terms of trueness, precision and detection and quantification limits. Percentages of recovery varied from 69% to 122% with relative standard deviations below 24%. Detection limits ranged from 0.06 to 5 ng g−1 and quantification limits from 0.19 to 17 ng g−1 dry weight. Finally, the method was applied to the analysis of 7 mussel samples collected in the coast of Galicia (Spain). 8 OPEs were detected in these samples at concentrations ranging from the LOQ to 291 ng g−1 dry weight.
PB Elsevier
SN 0039-9140
YR 2019
FD 2019-10-12
LK http://hdl.handle.net/10347/20602
UL http://hdl.handle.net/10347/20602
LA eng
NO Castro et al. Determination of 18 organophosphorus flame retardants/plasticizers in mussel samples by matrix solidphase dispersion combined to liquid chromatography-tandem mass spectrometry, Talanta 208 (2019) 120470, doi: https://doi.org/10.1016/j.talanta.2019.120470.
NO This work was financially supported by the Spanish Agencia Estatal de Investigación (ref. CTM2017-84763-C3-2-R), the Galician Council of Culture, Education and Universities (ref. ED431C2017/36 and Verónica Castro predoctoral contract, ref. ED481A-2017/156), cofunded by FEDER/ERDF
DS Minerva
RD 28 abr 2026