RT Journal Article
T1 Contact lenses that transform gold into nanoparticles for prophylaxis of light-related events and photothermal therapy
A1 Álvarez Lorenzo, Carmen
A1 Vivero López, María
A1 Concheiro Nine, Ángel Joaquín
K1 Contact lenses
K1 Gold nanoparticles
K1 Silicone hydrogel
K1 Photothermal therapy
K1 Autoclave
K1 Light-filter medical device
K1 Anisotropic gold particles
AB This work describes for first time how anisotropic gold nanoparticles (AuNPs) can be spontaneously formed inside preformed contact lenses (CLs) avoiding the use of additional reductant agents (reagent-free) through a precise tunning of the monomeric composition, the saline concentration, and the application of steam heat sterilization. Protocols to generate AuNPs in solution using inorganic or small organic reductants are widely available. Differently, gold precursors interactions with polymer networks have been overlooked and, thus, the interest of chemically cross-linked hydrogels as organic reductants is still to be elucidated. In the ocular field, incorporation of AuNPs to CLs may expand their applications in prophylaxis, therapy and diagnosis. To carry out the work, a variety of hydrogels and commercially available CLs were incubated with gold salt solution without any other chemical reagent. AuNPs formation was monitored by changes in localized surface plasmon resonance (LSPR) bands and quantifying the gold sorbed. Only silicone hydrogels induced AuNPs formation at room temperature in few days; methacrylic acid red-shifted the LSPR band (550–600 nm), while monomers bearing F hindered the reduction. Storage of hydrogels in the gold precursor solution allowed a gradual formation of anisotropic AuNPs, which could be stopped at any time by washing the hydrogel with water. The developed CLs behave as efficient filters against highly penetrant light and also exhibit photoresponsiveness as demonstrated as rapid (10 s), focused mild hyperthermia when irradiated with green, red and NIR lasers
PB Elsevier
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30671
UL http://hdl.handle.net/10347/30671
LA eng
NO International Journal of Pharmaceutics 641 (2023) 123048
NO The work was supported by MCIN [PID 2020-113881RB-I00/AEI/10.13039/501100011033], Spain, FEDER and Xunta de Galicia [ED431C 2020/17]
DS Minerva
RD 27 abr 2026