RT Journal Article
T1 Effect of penetration enhancers on drug nail permeability from cyclodextrin/poloxamer-soluble polypseudorotaxane-based nail lacquers
A1 Cutrín Gómez, Elena
A1 Anguiano Igea, Soledad
A1 Delgado Charro, M Begoña
A1 Gómez Amoza, José Luis
A1 Otero Espinar, Francisco Javier
K1 Transungual drug delivery
K1 Nail
K1 Medicated nail lacquers
K1 Onychomycosis
K1 Nail psoriasis
K1 Polypseudorotaxanes
K1 Methyl-β-cyclodextrin
K1 Poloxamers
K1 Ciclopirox olamine
K1 Clobetasol propionate
K1 Penetration enhancer
AB Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low permeability of drugs in the nail plaque precludes the efficacy of local treatments. The use of penetration enhancers can increase drug permeability and improve the efficacy of the treatment of nail pathologies. In this work, different chemical substances have been evaluated as potential penetration enhancers. With this aim, the effect of different substances such as sodium lauryl sulfate (SLS), polyethylene glycol 300 (PEG 300), carbocysteine, N-acetylcysteine, lactic acid, potassium phosphate, Labrasol® and Labrafil® in the microstructure, nail surface and drug permeability has been evaluated. The models obtained by mercury intrusion porosimetry and PoreXpert™ software show a more porous structure in nails treated with different enhancers. Permeation studies with bovine hooves and nails revealed that all the hydroalcoholic lacquers developed, and particularly those prepared with SLS, provide better nail penetration of the drugs ciclopirox olamine and clobetasol propionate. Results have shown that the increase of the drug penetration in the nail is caused by the formation of a porous random microstructure and by the decrease of the contact angle between lacquers and the surface or the nail plaque. The presence of SLS produces an improvement in the spreading of the solution on the nail surface and promotes the penetration of the solution into the nail pores. The hydroalcoholic lacquer, elaborated with cyclodextrin/poloxamer soluble polypseudorotaxane and sodium lauryl sulfate as an enhancer, allowed the rate of diffusion and penetration of the active ingredient within the nail to be significantly higher than obtained with the reference lacquers when using either ciclopirox olamine or clobetasol propionate as the active ingredient
PB MDPI
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22546
UL http://hdl.handle.net/10347/22546
LA eng
NO Cutrín-Gómez, E.; Anguiano-Igea, S.; Delgado-Charro, M.B.; Gómez-Amoza, J.L.; Otero-Espinar, F.J. Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers. Pharmaceutics 2018, 10, 273
NO This research was funded by the Technology Transfer Accelerator of the University of Santiago deCompostela and by Xunta de Galicia grant numbers GRC2013/015 and GPC2017/015. E.C.-G. was supported bya predoctoral grant from Xunta de Galicia
DS Minerva
RD 24 abr 2026