RT Dissertation/Thesis
T1 Zebrafish as a model organism for the study of toxicity and effectiveness of new antitumor therapies
A1 Gutiérrez Lovera, Carlha Rodmar
K1 Zebrafish
K1 Toxicidad
K1 Antitumoral drug
AB The zebrafish have many advantages that led to be a model organism with a great potential in translational research. The zebrafish embryos are an ideal platform to evaluate novel cancer therapies. For this reason, the main goal of this thesis has been evaluating the therapeutic potential of different anticancer therapies in zebrafish embryos. To accomplish this, we evaluated the toxicity in vitro and in vivo of some commonly used anticancer drugs in order to determinate crucial toxicological profiles for zebrafish xenograft studies. Additionally, we develop a newly nanoemulsion based on the anticancer drug edelfosine which let us to study parameters such as toxicity, biodistribution and efficacy in xenografted zebrafish models.
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23184
UL http://hdl.handle.net/10347/23184
LA eng
DS Minerva
RD 26 abr 2026