RT Journal Article
T1 Fish and sea products consumption and allergic rhinitis: A multicenter case–control study
A1 Regueira Méndez, Carlos
A1 Mallah, Narmeen
A1 Saulyte, Jurgita
A1 González Barcala, Francisco Javier
A1 Takkouche, Bahi
K1 Rhinitis
K1 Case–control studies
K1 Fatty acids
K1 Fishes
K1 Seafood
K1 Allergic
AB BackgroundThe association of allergic diseases with the intake of fish-derived proteins and fatty acids remains unclear, with studies showing divergent results. We aimed to examine the association of those nutrients with the occurrence of allergic rhinitis (AR).MethodsA multicenter case–control study was conducted with 411 AR cases and 477 controls. Adjusted odds ratios (OR) of AR and their 95 % confidence intervals (CI) were estimated using multivariate logistic regression models. Stratified analyses by fish type and macronutrient were undertaken.ResultsBlue fish consumption, except tuna, is associated with an important decrease in the odds of AR (1 serving/week: OR = 0.46; 95%CI: 0.27–0.80; 2 servings/week: OR = 0.30; 95%CI: 0.17–0.54; 3–4 servings/week: OR = 0.38; 95%CI: 0.20–0.68). Conversely, compared to no intake, white fish consumption is associated with higher odds of AR (3 servings/week: OR = 5.49; 95%CI: 3.27–9.24).A high n-6/n-3 polyunsaturated fatty acids (PUFAs) ratio is associated with higher odds of AR (OR = 1.79; 95%CI: 1.03–3.13 for the highest intake level compared to the lowest). High intake of n-3 PUFAs is associated with substantially lower odds of AR ranging between 46 % and 58 % (stearidonic acid OR = 0.42; 95%CI: 0.24–0.74; eicosapentaenoic acid OR = 0.45; 95%CI: 0.25–0.80; and docosapentaenoic acid OR = 0.54; 95%CI: 0.31–0.96).ConclusionsA high intake of blue fish, except tuna, is associated with lower odds of AR while that of white fish has an opposite association with the disease occurrence.
PB Elsevier
SN 0261-5614
YR 2025
FD 2025-06
LK https://hdl.handle.net/10347/43303
UL https://hdl.handle.net/10347/43303
LA eng
NO References  Regueira, C., Mallah, N., Saulyte, J., González-Barcala, F., & Takkouche, B. (2025). Fish and sea products consumption and allergic rhinitis: A multicenter case–control study. Clinical Nutrition, 49, 42–49. 10.1016/j.clnu.2025.04.005
NO This work was funded by a grant from Carlos III Health Institute (PI10/01295), Madrid, Spain, and FEDER.
DS Minerva
RD 4 may 2026