RT Journal Article
T1 Mixed Production of Filamentous Fungal Spores for Preventing Soil-Transmitted Helminth Zoonoses: A Preliminary Analysis
A1 Arias Vázquez, María Sol
A1 Cazapal Monteiro, Cristiana Filipa
A1 Paz Silva, Adolfo
A1 Sánchez-Andrade Fernández, Rita
A1 Mendoza de Gives, Pedro
AB Helminth zoonoses are parasitic infections shared by humans and animals, being the soil-transmitted helminths (STHs) mainly caused by roundworms (ascarids) and hookworms. This study was aimed to assess the individual and/or mixed production of two helminth-antagonistic fungi, one ovicide (Mucor circinelloides) and other predator (Duddingtonia flagrans). Fungi were grown both in Petri plates and in a submerged culture (composed by water, NaCl, Na2HPO4 · 12 H2O, and wheat (Triticum aestivum)). A Fasciola hepatica recombinant protein (FhrAPS) was incorporated to the cultures to improve fungal production. All the cultured plates showed fungal growth, without difference in the development of the fungi when grown alone or mixed. High counts of Mucor spores were produced in liquid media cultures, and no significant differences were achieved regarding single or mixed cultures, or the incorporation of the FhrAPS. A significantly higher production of Duddingtonia spores after the incorporation of the FhrAPS was observed. When analyzing the parasiticide efficacy of the fungal mixture, viability of T. canis eggs reduced to 51%, and the numbers of third stage cyathostomin larvae reduced to 4%. It is concluded, the capability of a fungal mixture containing an ovicide (Mucor) and a predator species (Duddingtonia) for growing together in a submerged medium containing the FhrAPS offers a very interesting tool for preventing STHs.
PB Hindawi
SN 2314-6133
YR 2013
FD 2013
LK http://hdl.handle.net/10347/22227
UL http://hdl.handle.net/10347/22227
LA eng
NO Arias, M. S., Cazapal-Monteiro, C. F., Suárez, J., Miguélez, S., Francisco, I., Arroyo, F. L., ... & Mendoza de Gives, P. (2013). Mixed production of filamentous fungal spores for preventing soil-transmitted helminth zoonoses: a preliminary analysis. BioMed research international, 2013.
NO This work was partly supported by the Research Projects 10MDS261023PR (Xunta de Galicia, Spain) and AGL2012-34355 (Ministerio de Economía y Competitividad, Spain; FEDER)
DS Minerva
RD 24 abr 2026