RT Journal Article
T1 Usefulness of positron emission tomography in the examination of hilar and mediastinal lymphadenopathies in patients with suspicion of lung cancer
A1 Pereiro Brea, Tara
A1 Golpe Gómez, Antonio
A1 Golpe Sánchez, Antonio Miguel
A1 Valdés Cuadrado, Luis
A1 Martínez de Alegría, Anxo
A1 Carreira Villamor, José Martin
A1 Ruano Raviña, Alberto
K1 Positron emission tomography
K1 Lung cancer
K1 Mediastinal lymphadenopathies
K1 Hilar Lymphadenopathies
AB Introduction. Lung cancer is a major health problem. Mediastinal staging performed with the aid of imaging techniques is essential for appropriate disease treatment and prognosis. Accordingly, this study aimed to ascertain the usefulness of positron emission tomography (PET) in mediastinal staging, establish the best maximum standardized uptake value (SUVmax) cutoff point, compare its usefulness to that of computed tomography (CT), and determine the influence of histological tumour subtype. Methods. We conducted a retrospective study across a period of 3 years on 128 patients with suspicion of lung cancer and analyzed their demographic and radiological characteristics using CT and PET to perform the mediastinal examination. Histology was regarded as the gold standard. Results. PET displayed a high sensitivity (95%) and negative predictive value (NPV) (92%), outperforming CT (89% and 85%, respectively). Percentage agreement with histology was also higher (0.207 and 0.241 for CT and PET, respectively; p < 0.001). Taking an SUVmax value of 0.5 as that which would ensure greatest diagnostic accuracy, S and NPV were 100%, though percentage agreement did not increase (0.189; p < 0.001). PET discriminatory power was not affected by histological tumour subtype. Conclusions. The results of our study indicate that PET might be a useful test for examination of the mediastinum in lung cancer patients. Its high NPV suggests that the absence of mediastinal uptake could be used to proceed to surgical treatment without the need for further tests or examinations. Nevertheless, studies directly aimed to answer this specific question are needed
PB Wiley
YR 2020
FD 2020-06-06
LK https://hdl.handle.net/10347/40448
UL https://hdl.handle.net/10347/40448
LA eng
NO Pereiro-Brea, Tara, Golpe-Gómez, Antonio, Golpe-Sánchez, Antonio Miguel, Valdés, Luís, Martínez de Alegría, Anxo, Carreira-Villamor, José Martín, Ruano-Raviña, Alberto, Usefulness of Positron Emission Tomography in the Examination of Hilar and Mediastinal Lymphadenopathies in Patients with Suspicion of Lung Cancer, Canadian Respiratory Journal, 2020, 7909543, 6 pages, 2020. https://doi.org/10.1155/2020/7909543
DS Minerva
RD 30 abr 2026