RT Journal Article
T1 Evaluation of the In Vitro and In Vivo Efficacy of Ruthenium Polypyridyl Compounds against Breast Cancer
A1 Lenis Rojas, Oscar
A1 Roma-Rodrigues, Catarina
A1 Fernandes, Alexandra
A1 Carvalho, Andreia
A1 Cordeiro, Sandra
A1 Guerra-Varela, Jorge
A1 Sánchez Piñón, Laura
A1 Vázquez García, Digna
A1 López-Torres, Margarita
A1 Fernández, Alberto
A1 Fernández, Jesús J.
K1 MCF7 zebrafish xenograft
K1 Ruthenium
K1 Polypyridyl compounds
K1 Cytotoxicit
K1 Cell death
K1 Cell cycle
AB The clinical success of cisplatin, carboplatin, and oxaliplatin has sparked the interest of medicinal inorganic chemistry to synthesize and study compounds with non-platinum metal centers. Despite Ru(II)–polypyridyl complexes being widely studied and well established for their antitumor properties, there are not enough in vivo studies to establish the potentiality of this type of compound. Therefore, we report to the best of our knowledge the first in vivo study of Ru(II)–polypyridyl complexes against breast cancer with promising results. In order to conduct our study, we used MCF7 zebrafish xenografts and ruthenium complexes [Ru(bipy)2(C12H8N6-N,N)][CF3SO3]2 Ru1 and [{Ru(bipy)2}2(μ-C12H8N6-N,N)][CF3SO3]4 Ru2, which were recently developed by our group. Ru1 and Ru2 reduced the tumor size by an average of 30% without causing significant signs of lethality when administered at low doses of 1.25 mg·L−1. Moreover, the in vitro selectivity results were confirmed in vivo against MCF7 breast cancer cells. Surprisingly, this work suggests that both the mono- and the dinuclear Ru(II)–polypyridyl compounds have in vivo potential against breast cancer, since there were no significant differences between both treatments, highlighting Ru1 and Ru2 as promising chemotherapy agents in breast cancer therapy.
PB MDPI
SN 1422-0067
YR 2021
FD 2021-08-18
LK http://hdl.handle.net/10347/32014
UL http://hdl.handle.net/10347/32014
LA eng
NO Lenis-Rojas, O.A.; Roma-Rodrigues, C.; Fernandes, A.R.; Carvalho, A.; Cordeiro, S.; Guerra-Varela, J.; Sánchez, L.; Vázquez-García, D.; López-Torres, M.; Fernández, A.; et al. Evaluation of the In Vitro and In Vivo Efficacy of Ruthenium Polypyridyl Compounds against Breast Cancer. Int. J. Mol. Sci. 2021, 22, 8916. https://doi.org/10.3390/ijms22168916
NO The UDC authors acknowledge the financial support received from the Xunta de Galicia (Galicia, Spain) under the Grupos de Referencia Competitiva Programme: Project ED431C 2018/39 (Quimolmat Group). The Portuguese authors acknowledge the Portuguese Foundation for Science and Technology (FCT—Fundação para a Ciência e a Tecnologia) for funding through projects PEst 2015-2020, UID/Multi/04349/2013, RECI/QEQ-QIN/0189/2012, and UID/QUI/00100/2020. This work was financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB.
DS Minerva
RD 22 abr 2026