RT Book,_Section
T1 Evidence of cyclodextrin aggregation obtained with Fluorescence Correlation Spectroscopy
A1 Al-Soufi, Wajih
A1 Granadero, Daniel
A1 Bordello Malde, Jorge
A1 Freire Rodríguez, Sonia
A1 Piñeiro Maseda, Lucas
A1 Novo, Mercedes
K1 Cyclodextrin
K1 Aggregation
K1 Fluorescence Correlation Spectroscopy
AB We have studied the complexation between an adamantane derivative labelled with the fluorescent probe Alexa 488 and the three natural cyclodextrins (-, - and -CD) by Fluorescence Correlation Spectroscopy (FCS), demonstrating the ability of this technique to detect association and to determine the corresponding equilibrium constants with no need for changes in the fluorescence properties of the guest. At low CD concentrations the observed increase of the diffusion time of the probe is mainly due to the complexation of the adamantyl moiety, but further changes are observed when increasing CD concentration that are attributed to the formation of CD aggregates. These aggregates appear at quite low CD concentrations and seem to be formed by a small number of CD molecules. These results show the potential of FCS for the study of CD self-assembly, a recently-recognized phenomenon that could be used to improve certain applications of CDs
PB MDPI
SN 3-906980-24-3
YR 2010
FD 2010
LK http://hdl.handle.net/10347/26886
UL http://hdl.handle.net/10347/26886
LA eng
NO Proceedings of the 14th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2010, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-14-00491
NO The 14th International Electronic Conference on Synthetic Organic Chemistry session Polymer Chemistry
NO The authors thank the Ministerio de Ciencia e Innovación and the Xunta de Galicia for financial support (CTQ2007-68057-C02-02/BQU, INCITE09E2R209064ES, INCITE09262304PR, 2009/029). J. Bordello and S. Freire thank Ministerio de Educación and Xunta de Galicia for scholarships
DS Minerva
RD 22 abr 2026