RT Journal Article
T1 Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa
A1 Steward, Trevor
A1 Mestre Bach, Gemma
A1 Granero, Roser
A1 Sánchez, Isabel
A1 Riesco, Nadine
A1 Vintró Alcaraz, Cristina
A1 Sauchelli, Sarah
A1 Jiménez Murcia, Susana
A1 Agüera, Zaida
A1 Fernández García, Jose C.
A1 Garrido Sánchez, Lourdes
A1 Tinahones Madueño, Francisco José
A1 Casanueva Freijo, Felipe
A1 Baños, Rosa M.
A1 Botella, Cristina
A1 Crujeiras Martínez, Ana Belén
A1 Torre, Rafael de la
A1 Fernández Real, Jose M.
A1 Frühbeck, Gema
A1 Ortega, Francisco J.
A1 Rodríguez, Amaia
A1 Menchón, José M.
A1 Fernández Aranda, Fernando
K1 Cognitive neuroscience
K1 Endocrine system and metabolic diseases
K1 Psychiatric disorders
AB Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OXA) concentrations and neuropsychological functioning in adult women with AN, and a matched control group. Fasting plasma OXA concentrations were taken in 51 females with AN and in 51 matched healthy controls. Set-shifting was assessed using the Wisconsin Card Sorting Test (WCST), whereas decision making was measured using the Iowa Gambling Task (IGT). The AN group exhibited lower plasma OXA levels than the HC group. Lower mean scores were obtained on the IGT in AN patients. WCST perseverative errors were signifcantly higher in the AN group compared to HC. In both the AN and HC group, OXA levels were negatively correlated with WCST non-perseverative errors. Reduced plasma OXA concentrations were found to be associated with set-shifting impairments in AN. Taking into consideration the function of orexins in promoting arousal and cognitive fexibility, future studies should explore whether orexin partly underpins the cognitive impairments found in AN
PB Nature Publishing Group
YR 2019
FD 2019-05-07
LK http://hdl.handle.net/10347/21537
UL http://hdl.handle.net/10347/21537
LA eng
NO Steward, T., Mestre-Bach, G., Granero, R. et al. Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa. Sci Rep 9, 7910 (2019). https://doi.org/10.1038/s41598-019-44450-6
NO We thank CERCA Programme/Generalitat de Catalunya for institutional support. This manuscript and researchwas supported by grants from the Ministerio de Economía y Competitividad (PSI2015-68701-R), Ministerio deSanidad, Servicios Sociales e Igualdad (PR338/17), Instituto de Salud Carlos III (ISCIII) (FIS PI14/00290 andPI17/01167) and co-funded by FEDER funds/European Regional Development Fund (ERDF), a way to buildEurope. CIBERObn and CIBERSAM are both initiatives of ISCIII. The funders had no role in the study design,data collection and analysis, decision to publish, or preparation of the manuscript. This research was supported by a PNSD (PR338/17-MSSSI) grant. GMB is supported by a predoctoral AGAUR grant (2018 FI_B2 00174), grantco-funded by the European Social Fund (ESF) “ESF”, investing in your future. With the support of the Secretariatfor Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia. CVAis supported by a predoctoral Grant of the Ministerio de Educación, Cultura y Deporte (FPU16/01453). ABC isfunded by a research contract “Miguel Servet” (CP17/00088) from the ISCIII
DS Minerva
RD 28 abr 2026