RT Journal Article
T1 Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs
A1 Moya, José S.
A1 Martínez Insua, Arturo
A1 López-Píriz, Roberto
A1 Guitián Rivera, Francisco
A1 Díaz, Luis A.
A1 Esteban Tejada, Leticia
A1 Cabal, Belén
A1 Sket, Federico
A1 Fernández-García, Elisa
A1 Tomsia, Antoni P.
A1 Torrecillas, Ramón
K1 Health care
K1 Diseases
AB Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P2O5 glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue engineering. 
PB Nature Publishing Group
SN 2045-2322
YR 2016
FD 2016-08-12
LK http://hdl.handle.net/10347/16313
UL http://hdl.handle.net/10347/16313
LA eng
NO Moya, J. S. et al. Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs. Sci. Rep. 6, 31478; doi: 10.1038/srep31478 (2016)
NO This work was supported by the Spanish Ministry of Science and Innovation (MICINN) under the projectsMAT2012-38645. A.P. Tomsia work was supported by the National Institutes of Health/National Institute ofDental and Craniofacial Research (NIH/NIDCR) Grant No. 1R01DE015633
DS Minerva
RD 28 abr 2026