RT Journal Article
T1 Temporal summation of second pain is affected by cognitive load
A1 Rubal-Otero, Lara
A1 Gil Ugidos, Antonio
A1 González Villar, Alberto Jacobo
A1 Carrillo de la Peña, María Teresa
K1 Attention
K1 Cognitive load
K1 Event-related potentials (ERPs)
K1 Global field power (GFP)
K1 Temporal summation of second pain (TSSP)
K1 Working memory
AB This work attempted to clarify the interaction of cognition and pain sensitization during a paradigm of Temporal Summation of Second Pain (TSSP). We analyzed pain ratings and electroencephalographic (EEG) activity obtained from 21 healthy participants during the presentation of four experimental conditions that differed in the manipulation of attention to painful stimuli or working memory load (Attention to hand & TSSP; 0-back & TSSP (low cognitive load); 2-back & TSSP (high cognitive load); 2-back (without pain)). We found that the TSSP was reduced when the attention was diverted and the cognitive load increased, and this reduction was accompanied by higher midfrontal theta activity and lower posterior alpha and central beta activity. Although it is well established that TSSP is a phenomenon that occurs at the spinal level, here we show that it is also affected by supraspinal attentional mechanisms. Delivery of painful repeated stimuli did not affect the performance of the 2-back task but was associated with smaller amplitudes of attentional event-related potentials (ERPs) after standard stimuli (not the target). The study of brain activity during TSSP allowed to clarify the role of top-down attentional modulation in pain sensitization processes. Results contribute to a better understanding of cognitive dysfunction in pain conditions and reinforce the use of therapeutic strategies based on distracting attention away from pain.
PB Wiley
SN 0360-4012
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34894
UL http://hdl.handle.net/10347/34894
LA eng
NO Rubal-Otero, L., Gil-Ugidos, A., Villar, A. J. G., & Carrillo-de-la-Peña, M. T. (2024). Temporal summation of second pain is affected by cognitive load. Journal of Neuroscience Research, 102, e25363. https://doi.org/10.1002/jnr.25363
NO The authors express our gratitude to all the participants who tookpart in this study. In addition, the authors acknowledge the financialsupport without which this study could not have been performed.This work was supported by the Spanish Government (Ministry of Science and Innovation; ref: PID2019-107986RB-I00). In addition,Gonzalez-Villar, A.J. was supported by a grant from the PortugueseFoundation for Science and Technology within the scope of theIndividual Call for Stimulus to Scientific Employment 2017.
DS Minerva
RD 27 abr 2026