RT Journal Article
T1 Effects of persistent binge drinking on brain structure in emerging adults: a longitudinal study
A1 Pérez García, José Manuel
A1 Cadaveira Mahía, Fernando
A1 Canales-Rodríguez, Erick Jorge
A1 Suárez Suárez, Samuel
A1 Rodríguez Holguín, Socorro
A1 Corral Varela, María Montserrat
A1 Blanco Ramos, Javier
A1 Doallo Pesado, Sonia
K1 Binge drinking
K1 Brain structure
K1 Longitudinal
K1 Sex differences
K1 Surface-based morphometry
K1 Emerging adulthood
K1 Alcohol
K1 Consumo intensivo
K1 Estrutura cerebral
K1 Lonxitudinal
K1 Morfometría de superficie
K1 Adultos xóvenes
AB Previous cross-sectional research has largely associated binge drinking (BD) with changes in volume and thickness during adolescence and early adulthood. Nevertheless, the long-term alcohol-related effects on gray matter features in youths who had maintained a BD pattern over time have not yet been sufficiently explored. The present study aimed to assess group differences both cross-sectionally and longitudinally [using symmetric percent change (SPC)] on several structural measures (i.e., thickness, surface area, volume). For this purpose, magnetic resonance imaging was recorded twice within a 2-year interval; at baseline (18–19 years) and a follow-up (20–21 years). The sample included 44 university students who were classified as 16 stable binge drinkers (8 females) and 28 stable controls (13 females). Whole-brain analysis showed larger insular surface area in binge drinkers relative to controls at follow-up (cluster-wise p = 0.045). On the other hand, region of interest (ROI) analyses on thickness also revealed a group by sex interaction at follow-up (p = 0.005), indicating that BD males had smaller right rostral middle frontal gyrus thickness than both control males (p = 0.011) and BD females (p = 0.029). Similarly, ROI-based analysis on longitudinal data showed a group by sex interaction in the right nucleus accumbens (p = 0.009) which revealed a decreased volume across time in BD males than in control males (p = 0.007). Overall, continued BD pattern during emerging adulthood appears to lead to gray matter abnormalities in regions intimately involved in reward processing, emotional regulation and executive functions. Notably, some anomalies varied significantly depending on sex, suggesting a sex-specific impact of BD on typical neurodevelopment processes
YR 2022
FD 2022
LK http://hdl.handle.net/10347/28983
UL http://hdl.handle.net/10347/28983
LA eng
NO Pérez-García, JM; Cadaveira, F; Canales-Rodríguez, E.J.; Suárez-Suárez, S; Rodríguez Holguín, S.; Corral, M.; Blanco-Ramos, J; Doallo, S. (2022). Effects of persistent binge drinking on brain structure in emerging adults: a longitudinal study. Frontiers in Psychiatry, 13, 935043. doi:10.3389/fpsyt.2022.935043
NO This work was supported by grants from the Spanish Ministerio de Sanidad, Servicios Sociales e Igualdad, Plan Nacional sobre Drogas (PNSD 2015/034), Ministerio de Economìa y Competitividad (PSI2015-70525-P) co-funded for European Regional Development Fund, MCIN/ AEI/10.13039/501100011033 (grant PID2020-113487RB-I00), and Xunta de Galicia (GRC ED431C 2017/06; ED431C 2021/08). JP-G was supported by the FPU program from the Spanish Ministerio de Educacion, Cultura y Deporte (FPU16/01573). EC-R was supported by the Swiss National Science Foundation (SNSF, Ambizione grant PZ00P2 185814).
DS Minerva
RD 27 abr 2026